FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000739586> ?p ?o ?g. }

• W2000739586 endingPage "396" @default.
• W2000739586 startingPage "388" @default.
• W2000739586 abstract "We propose that hyperinsulinemia stimulates protein synthesis when postabsorptive plasma amino acid (AA) concentrations are maintained. During a euglycemic hyperinsulinemic clamp, many AA, notably the branched-chain amino acids (BCAA), decline markedly. Therefore, we tested whether individual plasma AA could be maintained within the range of postabsorptive concentrations to assess the effects of insulin, infused at 40 mU/m(2) x min on whole-body protein and glucose metabolism, using [1-(13)C]-leucine and [3-(3)H]-glucose methodology. Validation studies of background [(13)C] enrichment and breath (13)CO(2) recovery factors were performed in a subset of 6 subjects. In 10 healthy, young men, infusion rates of an AA solution were based on fluorometric determinations of total BCAA every 5 minutes. All 21 plasma AA remained in the target range; 15, including the BCAA, alanine, and glycine were within 13% of baseline, and only 6 (Thr, His, Arg, Asn, Cit, Tyr) varied more (18% to 42%). Notably, both leucine flux and nonoxidative leucine R(d) (protein synthesis) increased with insulin (2.36 +/- 0.06 to 2.81 +/- 0.10 and 1.79 +/- 0.05 to 2.18 +/- 0.10 micromol/kg fat-free mass (FFM) x min, respectively; P <.0005) while leucine oxidation only tended to increase (P =.05) and endogenous leucine R(a) (protein breakdown) decreased by 18% (2.36 +/- 0.06 to 1.94 +/- 0.09 micromol/kg FFM x min; P <.0005), resulting in a marked elevation of net protein synthesis (-0.57 +/- 0.02 to 0.24 +/- 0.02 micromol/kg FFM x min; P <.0000001). Thus, in vivo protein anabolism was induced when maintaining postabsorptive plasma amino acid concentrations during hyperinsulinemia through a suppression of whole-body protein breakdown, no significant change in oxidation and an elevation of synthesis compared with postabsorptive conditions." @default.
• W2000739586 created "2016-06-24" @default.
• W2000739586 creator A5015483657 @default.
• W2000739586 creator A5035803269 @default.
• W2000739586 creator A5073408714 @default.
• W2000739586 creator A5075367927 @default.
• W2000739586 creator A5089940284 @default.
• W2000739586 date "2004-03-01" @default.
• W2000739586 modified "2023-10-16" @default.
• W2000739586 title "The hyperinsulinemic amino acid clamp increases whole-body protein synthesis in young subjects" @default.
• W2000739586 cites W1553335616 @default.
• W2000739586 cites W1577717356 @default.
• W2000739586 cites W1673028275 @default.
• W2000739586 cites W1772107894 @default.
• W2000739586 cites W1911492277 @default.
• W2000739586 cites W1955270617 @default.
• W2000739586 cites W1957263415 @default.
• W2000739586 cites W1969139891 @default.
• W2000739586 cites W1978893185 @default.
• W2000739586 cites W1981107426 @default.
• W2000739586 cites W1987545671 @default.
• W2000739586 cites W1999177368 @default.
• W2000739586 cites W1999244656 @default.
• W2000739586 cites W2007397474 @default.
• W2000739586 cites W2007542361 @default.
• W2000739586 cites W2021794489 @default.
• W2000739586 cites W2049726973 @default.
• W2000739586 cites W2052998622 @default.
• W2000739586 cites W2079956153 @default.
• W2000739586 cites W2082543369 @default.
• W2000739586 cites W2085185559 @default.
• W2000739586 cites W2090190154 @default.
• W2000739586 cites W2109555667 @default.
• W2000739586 cites W2111221005 @default.
• W2000739586 cites W2119574872 @default.
• W2000739586 cites W2125365329 @default.
• W2000739586 cites W2162254318 @default.
• W2000739586 cites W2207948165 @default.
• W2000739586 cites W2602651684 @default.
• W2000739586 cites W4230801048 @default.
• W2000739586 cites W4231690839 @default.
• W2000739586 cites W4231901101 @default.
• W2000739586 cites W4233017605 @default.
• W2000739586 cites W4236428351 @default.
• W2000739586 cites W4245208848 @default.
• W2000739586 cites W4253688138 @default.
• W2000739586 doi "https://doi.org/10.1016/j.metabol.2003.09.016" @default.
• W2000739586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15015153" @default.
• W2000739586 hasPublicationYear "2004" @default.
• W2000739586 type Work @default.
• W2000739586 sameAs 2000739586 @default.
• W2000739586 citedByCount "54" @default.
• W2000739586 countsByYear W20007395862012 @default.
• W2000739586 countsByYear W20007395862013 @default.
• W2000739586 countsByYear W20007395862014 @default.
• W2000739586 countsByYear W20007395862015 @default.
• W2000739586 countsByYear W20007395862016 @default.
• W2000739586 countsByYear W20007395862017 @default.
• W2000739586 countsByYear W20007395862018 @default.
• W2000739586 countsByYear W20007395862020 @default.
• W2000739586 countsByYear W20007395862021 @default.
• W2000739586 countsByYear W20007395862022 @default.
• W2000739586 crossrefType "journal-article" @default.
• W2000739586 hasAuthorship W2000739586A5015483657 @default.
• W2000739586 hasAuthorship W2000739586A5035803269 @default.
• W2000739586 hasAuthorship W2000739586A5073408714 @default.
• W2000739586 hasAuthorship W2000739586A5075367927 @default.
• W2000739586 hasAuthorship W2000739586A5089940284 @default.
• W2000739586 hasConcept C126322002 @default.
• W2000739586 hasConcept C134018914 @default.
• W2000739586 hasConcept C185592680 @default.
• W2000739586 hasConcept C197683979 @default.
• W2000739586 hasConcept C2776580952 @default.
• W2000739586 hasConcept C2777391703 @default.
• W2000739586 hasConcept C2777573094 @default.
• W2000739586 hasConcept C2777756961 @default.
• W2000739586 hasConcept C2778808658 @default.
• W2000739586 hasConcept C2779306644 @default.
• W2000739586 hasConcept C2779856020 @default.
• W2000739586 hasConcept C2780352109 @default.
• W2000739586 hasConcept C2780988686 @default.
• W2000739586 hasConcept C515207424 @default.
• W2000739586 hasConcept C55493867 @default.
• W2000739586 hasConcept C62231903 @default.
• W2000739586 hasConcept C71924100 @default.
• W2000739586 hasConcept C86803240 @default.
• W2000739586 hasConceptScore W2000739586C126322002 @default.
• W2000739586 hasConceptScore W2000739586C134018914 @default.
• W2000739586 hasConceptScore W2000739586C185592680 @default.
• W2000739586 hasConceptScore W2000739586C197683979 @default.
• W2000739586 hasConceptScore W2000739586C2776580952 @default.
• W2000739586 hasConceptScore W2000739586C2777391703 @default.
• W2000739586 hasConceptScore W2000739586C2777573094 @default.
• W2000739586 hasConceptScore W2000739586C2777756961 @default.
• W2000739586 hasConceptScore W2000739586C2778808658 @default.
• W2000739586 hasConceptScore W2000739586C2779306644 @default.
• W2000739586 hasConceptScore W2000739586C2779856020 @default.
• W2000739586 hasConceptScore W2000739586C2780352109 @default.

• next