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- W2000740045 abstract "In this issue of Blood, Romain et al demonstrate that natural killer (NK) cell–mediated killing of tumor cells coated with the Fc-optimized CD33 antibody DLE-HuM195 reveals a distinct kinetic profile. The presented work gives important novel insights into the mechanism of effector cell–mediated target cell killing triggered by Fc-engineered antibodies and explains how they achieve a higher antibody-dependent cell-mediated cytotoxicity (ADCC) potency than native immunoglobulin G1 (IgG1) antibodies. Using time-lapse imaging microscopy in nanowell grids (TIMING), the authors were able to demonstrate at the single-cell level that antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells." @default.
- W2000740045 created "2016-06-24" @default.
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- W2000740045 date "2014-11-20" @default.
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- W2000740045 title "Fc-optimized antibodies quickly pull the trigger" @default.
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- W2000740045 doi "https://doi.org/10.1182/blood-2014-10-602219" @default.
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