FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000740649> ?p ?o ?g. }

• W2000740649 endingPage "99" @default.
• W2000740649 startingPage "88" @default.
• W2000740649 abstract "Sculptured thin film (STF) substrates consist of nanocolumns with precise orientation, intercolumnar spacing, and optical anisotropy, which can be used as model biomaterial substrates to study the effect of homogenous nanotopogrophies on the three-dimensional distribution of adsorbed proteins. Generalized ellipsometry was used to discriminate between the distributions of adsorbed FN either on top of or within the intercolumnar void spaces of STFs, afforded by the optical properties of these precisely crafted substrates. Generalized ellipsometry indicated that STFs with vertical nanocolumns enhanced total FN adsorption two-fold relative to flat control substrates and the FN adsorption studies demonstrate different STF characteristics influence the degree of FN immobilization both on top and within intercolumnar spaces, with increasing spacing and surface area enhancing total protein adsorption. Mouse fibroblasts or mouse mesenchymal stem cells were subsequently cultured on STFs, to investigate the effect of highly ordered and defined nanotopographies on cell adhesion, spreading, and proliferation. All STF nanotopographies investigated in the absence of adsorbed FN were found to significantly enhance cell adhesion relative to flat substrates; and the addition of FN to STFs was found to have cell-dependent effects on enhancing cell–material interactions. Furthermore, the amount of FN adsorbed to the STFs did not correlate with comparative enhancements of cell–material interactions, suggesting that nanotopography predominantly contributes to the biocompatibility of homogenous nanocolumnar surfaces. This is the first study to correlate precisely defined nanostructured features with protein distribution and cell–nanomaterial interactions. STFs demonstrate immense potential as biomaterial surfaces for applications in tissue engineering, drug delivery, and biosensing." @default.
• W2000740649 created "2016-06-24" @default.
• W2000740649 creator A5033176531 @default.
• W2000740649 creator A5037997602 @default.
• W2000740649 creator A5046867296 @default.
• W2000740649 creator A5056977278 @default.
• W2000740649 creator A5067220785 @default.
• W2000740649 creator A5072182471 @default.
• W2000740649 creator A5082317701 @default.
• W2000740649 creator A5084689168 @default.
• W2000740649 creator A5085056101 @default.
• W2000740649 date "2015-05-01" @default.
• W2000740649 modified "2023-09-27" @default.
• W2000740649 title "Use of precisely sculptured thin film (STF) substrates with generalized ellipsometry to determine spatial distribution of adsorbed fibronectin to nanostructured columnar topographies and effect on cell adhesion" @default.
• W2000740649 cites W1535902400 @default.
• W2000740649 cites W1819128041 @default.
• W2000740649 cites W1964171229 @default.
• W2000740649 cites W1965751581 @default.
• W2000740649 cites W1966111995 @default.
• W2000740649 cites W1967197607 @default.
• W2000740649 cites W1969956160 @default.
• W2000740649 cites W1971963330 @default.
• W2000740649 cites W1972366145 @default.
• W2000740649 cites W1974721987 @default.
• W2000740649 cites W1975568346 @default.
• W2000740649 cites W1980951135 @default.
• W2000740649 cites W1982572731 @default.
• W2000740649 cites W1982912398 @default.
• W2000740649 cites W1985139725 @default.
• W2000740649 cites W1986565822 @default.
• W2000740649 cites W1988063557 @default.
• W2000740649 cites W1992190612 @default.
• W2000740649 cites W1997783326 @default.
• W2000740649 cites W2000907296 @default.
• W2000740649 cites W2004873606 @default.
• W2000740649 cites W2005929315 @default.
• W2000740649 cites W2007585211 @default.
• W2000740649 cites W2010253121 @default.
• W2000740649 cites W2010278203 @default.
• W2000740649 cites W2010721048 @default.
• W2000740649 cites W2011887766 @default.
• W2000740649 cites W2014648364 @default.
• W2000740649 cites W2014817128 @default.
• W2000740649 cites W2018708785 @default.
• W2000740649 cites W2022273314 @default.
• W2000740649 cites W2028183845 @default.
• W2000740649 cites W2029949813 @default.
• W2000740649 cites W2032275376 @default.
• W2000740649 cites W2033512828 @default.
• W2000740649 cites W2036833588 @default.
• W2000740649 cites W2039973857 @default.
• W2000740649 cites W2042722117 @default.
• W2000740649 cites W2043269952 @default.
• W2000740649 cites W2043491734 @default.
• W2000740649 cites W2045383620 @default.
• W2000740649 cites W2049020426 @default.
• W2000740649 cites W2050869999 @default.
• W2000740649 cites W2051477369 @default.
• W2000740649 cites W2054811699 @default.
• W2000740649 cites W2057757462 @default.
• W2000740649 cites W2057803857 @default.
• W2000740649 cites W2058044900 @default.
• W2000740649 cites W2058892201 @default.
• W2000740649 cites W2061261268 @default.
• W2000740649 cites W2063396709 @default.
• W2000740649 cites W2066200034 @default.
• W2000740649 cites W2068831263 @default.
• W2000740649 cites W2069200475 @default.
• W2000740649 cites W2075858828 @default.
• W2000740649 cites W2076648828 @default.
• W2000740649 cites W2078325328 @default.
• W2000740649 cites W2081418737 @default.
• W2000740649 cites W2082087069 @default.
• W2000740649 cites W2083814589 @default.
• W2000740649 cites W2085258854 @default.
• W2000740649 cites W2086162149 @default.
• W2000740649 cites W2091612911 @default.
• W2000740649 cites W2093863297 @default.
• W2000740649 cites W2102930960 @default.
• W2000740649 cites W2114376686 @default.
• W2000740649 cites W2118949739 @default.
• W2000740649 cites W2144764582 @default.
• W2000740649 cites W2152912998 @default.
• W2000740649 cites W2153746289 @default.
• W2000740649 cites W2172124859 @default.
• W2000740649 cites W2186500839 @default.
• W2000740649 cites W2312615585 @default.
• W2000740649 cites W2320170792 @default.
• W2000740649 cites W2331453431 @default.
• W2000740649 cites W3100201254 @default.
• W2000740649 cites W4246377120 @default.
• W2000740649 doi "https://doi.org/10.1016/j.actbio.2015.02.016" @default.
• W2000740649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25712389" @default.
• W2000740649 hasPublicationYear "2015" @default.
• W2000740649 type Work @default.
• W2000740649 sameAs 2000740649 @default.
• W2000740649 citedByCount "17" @default.
• W2000740649 countsByYear W20007406492015 @default.

• next