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• W2000740899 abstract "We have used a computer simulation system to examine formation of the chick primitive streak and to test the proposal (Wei and Mikawa Development 127 (2000) 87) that oriented cell division could account for primitive streak elongation. We find that this proposal is inadequate to explain elongation of the streak. In contrast, a correctly patterned model streak can be generated if two putative mechanisms are operative. First, a subpopulation of precursor cells that is known to contribute to the streak is assigned a specific, but simple, movement pattern. Second, additional cells within the epiblast are allowed to incorporate into the streak based on near-neighbor relations. In this model, the streak is cast as a steady-state system with continuous recruitment of neighboring epiblast cells, egress of cells into deeper layers and an internal pattern of cell movement. The model accurately portrays elongation and maintenance of a robust streak, changes in the composition of the streak and defects in the streak after experimental manipulation." @default.
• W2000740899 created "2016-06-24" @default.
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• W2000740899 date "2005-03-01" @default.
• W2000740899 modified "2023-09-25" @default.
• W2000740899 title "Formation of the chick primitive streak as studied in computer simulations" @default.
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• W2000740899 doi "https://doi.org/10.1016/j.jtbi.2004.10.008" @default.
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