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- W2000741184 abstract "A TaqI restriction fragment length polymorphism (RFLP) of the human transforming growth factor alpha (hTGF alpha) locus was analyzed in DNA from 63 normal individuals, 34 malignant melanoma (MM) cell lines, and 18 melanoma biopsy specimens. The frequency of a 2.7-kb allele (0.18) in MM cell lines was significantly higher (p less than 0.01) than in lymphoblastoid cell lines (LCLs) derived from unaffected controls (0.05). The frequency (0.14) in MM biopsies was similar to that in MM cell lines although, owing to the small numbers investigated, it was not significantly higher than in controls. In the case of 5 MM patients who were constitutionally heterozygous for alleles at the TGF alpha locus, no apparent losses of heterozygosity were observed in the corresponding tumour DNA. Thus, the constitutional presence of the 2.7-kb allele may be a risk factor for melanoma." @default.
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- W2000741184 date "1988-10-15" @default.
- W2000741184 modified "2023-09-24" @default.
- W2000741184 title "A TaqI RFLP of the human TGFα gene is significantly associated with cutaneous malignant melanoma" @default.
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- W2000741184 doi "https://doi.org/10.1002/ijc.2910420415" @default.
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