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- W2000741544 endingPage "7623" @default.
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- W2000741544 abstract "Significance Mutations in SMARCAL1, a DNA remodeling protein fundamental to genome integrity during replication, lead to the developmental disorder Schimke immuno-osseous dysplasia (SIOD). SMARCAL1-deficient cells exhibit collapsed replication forks, S-phase cell cycle arrest, increased chromosomal breaks, hypersensitivity to genotoxic agents, and chromosomal instability. SMARCAL1 facilitates replication restart by catalyzing ATP-dependent fork regression and branch migration, the mechanism of which is poorly understood. Here we provide structural and biochemical evidence for a conserved substrate recognition domain in DNA repair enzymes that couples ATP hydrolysis to remodeling of a variety of DNA structures, and provide insight into the role of this domain in replication fork stability and genome integrity." @default.
- W2000741544 created "2016-06-24" @default.
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- W2000741544 creator A5091143463 @default.
- W2000741544 date "2014-05-12" @default.
- W2000741544 modified "2023-10-16" @default.
- W2000741544 title "A structure-specific nucleic acid-binding domain conserved among DNA repair proteins" @default.
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- W2000741544 cites W1970578083 @default.
- W2000741544 cites W1977449047 @default.
- W2000741544 cites W1984530381 @default.
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- W2000741544 doi "https://doi.org/10.1073/pnas.1324143111" @default.
- W2000741544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4040553" @default.
- W2000741544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24821763" @default.
- W2000741544 hasPublicationYear "2014" @default.
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