FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000742077> ?p ?o ?g. }

• W2000742077 endingPage "5543" @default.
• W2000742077 startingPage "5537" @default.
• W2000742077 abstract "Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) continues to cause substantial economic losses to the global swine industry. PRRSV appears to inhibit synthesis of type I interferons (IFNs), such as IFN-α and -β, which are critical for the innate immunity and play an important role in the modulation of adaptive immunity. An atypical PRRSV strain, A2MC2, is able to induce type I IFNs in vitro. In this study, A2MC2 induction of neutralizing antibodies in vivo was compared with the Ingelvac PRRS modified live virus (MLV) vaccine strain and VR-2385 (a moderate virulent strain). Three-week-old pigs were exposed to these PRRSV strains via intranasal or intramuscular routes to also account for a possible effect of inoculation routes. The interferon-inducing A2MC2 resulted in earlier onset and significantly higher levels of PRRSV neutralizing antibodies than the MLV. In addition, the A2MC2-induced neutralizing antibodies were capable of neutralizing VR-2385, a heterologous strain. The pigs exposed via intranasal route had higher titers of neutralizing antibodies than those injected via intramuscular route. Macroscopic and microscopic lung lesions 14 days post-exposure indicated that A2MC2 had similar virulence in vivo as VR-2385. Pulmonary alveolar macrophages (PAMs) collected during the necropsy 14 days post-exposure in the A2MC2 group had higher level expression of IFN-γ than the MLV group. These results indicate that A2MC2 can be further explored for development of an improved vaccine against PRRS." @default.
• W2000742077 created "2016-06-24" @default.
• W2000742077 creator A5011078549 @default.
• W2000742077 creator A5025102682 @default.
• W2000742077 creator A5027162909 @default.
• W2000742077 creator A5028659991 @default.
• W2000742077 creator A5056436450 @default.
• W2000742077 creator A5067510720 @default.
• W2000742077 creator A5076424727 @default.
• W2000742077 creator A5082606902 @default.
• W2000742077 creator A5083578498 @default.
• W2000742077 date "2013-11-01" @default.
• W2000742077 modified "2023-10-18" @default.
• W2000742077 title "Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain" @default.
• W2000742077 cites W1978961805 @default.
• W2000742077 cites W1979633272 @default.
• W2000742077 cites W1985167539 @default.
• W2000742077 cites W1994629940 @default.
• W2000742077 cites W2000710670 @default.
• W2000742077 cites W2002435545 @default.
• W2000742077 cites W2015544673 @default.
• W2000742077 cites W2015721404 @default.
• W2000742077 cites W2022506220 @default.
• W2000742077 cites W2030627795 @default.
• W2000742077 cites W2031123850 @default.
• W2000742077 cites W2038778872 @default.
• W2000742077 cites W2046274883 @default.
• W2000742077 cites W2051013202 @default.
• W2000742077 cites W2055243308 @default.
• W2000742077 cites W2071365881 @default.
• W2000742077 cites W2081011858 @default.
• W2000742077 cites W2089568026 @default.
• W2000742077 cites W2097066834 @default.
• W2000742077 cites W2100160011 @default.
• W2000742077 cites W2101719759 @default.
• W2000742077 cites W2106908706 @default.
• W2000742077 cites W2125731727 @default.
• W2000742077 cites W2128729063 @default.
• W2000742077 cites W2140296277 @default.
• W2000742077 cites W2142017357 @default.
• W2000742077 cites W2151075263 @default.
• W2000742077 cites W2153393905 @default.
• W2000742077 cites W2153733982 @default.
• W2000742077 cites W2157227966 @default.
• W2000742077 cites W2167017590 @default.
• W2000742077 cites W2167202550 @default.
• W2000742077 cites W2169128111 @default.
• W2000742077 doi "https://doi.org/10.1016/j.vaccine.2013.09.023" @default.
• W2000742077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24063978" @default.
• W2000742077 hasPublicationYear "2013" @default.
• W2000742077 type Work @default.
• W2000742077 sameAs 2000742077 @default.
• W2000742077 citedByCount "38" @default.
• W2000742077 countsByYear W20007420772014 @default.
• W2000742077 countsByYear W20007420772015 @default.
• W2000742077 countsByYear W20007420772016 @default.
• W2000742077 countsByYear W20007420772017 @default.
• W2000742077 countsByYear W20007420772018 @default.
• W2000742077 countsByYear W20007420772019 @default.
• W2000742077 countsByYear W20007420772020 @default.
• W2000742077 countsByYear W20007420772021 @default.
• W2000742077 countsByYear W20007420772022 @default.
• W2000742077 countsByYear W20007420772023 @default.
• W2000742077 crossrefType "journal-article" @default.
• W2000742077 hasAuthorship W2000742077A5011078549 @default.
• W2000742077 hasAuthorship W2000742077A5025102682 @default.
• W2000742077 hasAuthorship W2000742077A5027162909 @default.
• W2000742077 hasAuthorship W2000742077A5028659991 @default.
• W2000742077 hasAuthorship W2000742077A5056436450 @default.
• W2000742077 hasAuthorship W2000742077A5067510720 @default.
• W2000742077 hasAuthorship W2000742077A5076424727 @default.
• W2000742077 hasAuthorship W2000742077A5082606902 @default.
• W2000742077 hasAuthorship W2000742077A5083578498 @default.
• W2000742077 hasConcept C104317684 @default.
• W2000742077 hasConcept C159047783 @default.
• W2000742077 hasConcept C159654299 @default.
• W2000742077 hasConcept C203014093 @default.
• W2000742077 hasConcept C2522874641 @default.
• W2000742077 hasConcept C2776178377 @default.
• W2000742077 hasConcept C2779261636 @default.
• W2000742077 hasConcept C2779341262 @default.
• W2000742077 hasConcept C2779819720 @default.
• W2000742077 hasConcept C2780115692 @default.
• W2000742077 hasConcept C55493867 @default.
• W2000742077 hasConcept C86803240 @default.
• W2000742077 hasConcept C8891405 @default.
• W2000742077 hasConceptScore W2000742077C104317684 @default.
• W2000742077 hasConceptScore W2000742077C159047783 @default.
• W2000742077 hasConceptScore W2000742077C159654299 @default.
• W2000742077 hasConceptScore W2000742077C203014093 @default.
• W2000742077 hasConceptScore W2000742077C2522874641 @default.
• W2000742077 hasConceptScore W2000742077C2776178377 @default.
• W2000742077 hasConceptScore W2000742077C2779261636 @default.
• W2000742077 hasConceptScore W2000742077C2779341262 @default.
• W2000742077 hasConceptScore W2000742077C2779819720 @default.
• W2000742077 hasConceptScore W2000742077C2780115692 @default.
• W2000742077 hasConceptScore W2000742077C55493867 @default.
• W2000742077 hasConceptScore W2000742077C86803240 @default.

• next