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• W2000744122 abstract "•A given GPCR structure can serve as the base to model other conformational states. •Modeling studies can explore conformational states globally or locally. •Virtual screening can be steered toward the retrieval of agonists or blockers. •Combining experimental and computational techniques might by the key to success. The biological response to the activation of G protein-coupled receptors (GPCRs) typically originates from the simultaneous modulation of various signaling pathways that lead to distinct biological consequences. Hence, ‘biased agonists’ (i.e., compounds that selectively activate one of the pathways while blocking the others) are highly sought-after molecules to provide fine-tuned pharmacological interventions. This review describes strategies that can be deployed to model the conformation of GPCRs in complex with ligands endowed with specific signaling profiles useful for the generation of hypotheses on the structural requirements for the activation of different signaling pathways or for rational computer-aided ligand discovery campaigns. In particular, it focuses on strategies potentially applicable to model the global or local conformational states of GPCRs stabilized by specific ligands. The biological response to the activation of G protein-coupled receptors (GPCRs) typically originates from the simultaneous modulation of various signaling pathways that lead to distinct biological consequences. Hence, ‘biased agonists’ (i.e., compounds that selectively activate one of the pathways while blocking the others) are highly sought-after molecules to provide fine-tuned pharmacological interventions. This review describes strategies that can be deployed to model the conformation of GPCRs in complex with ligands endowed with specific signaling profiles useful for the generation of hypotheses on the structural requirements for the activation of different signaling pathways or for rational computer-aided ligand discovery campaigns. In particular, it focuses on strategies potentially applicable to model the global or local conformational states of GPCRs stabilized by specific ligands." @default.
• W2000744122 created "2016-06-24" @default.
• W2000744122 creator A5021219075 @default.
• W2000744122 date "2014-06-01" @default.
• W2000744122 modified "2023-10-17" @default.
• W2000744122 title "Modeling G protein-coupled receptors in complex with biased agonists" @default.
• W2000744122 cites W1503765703 @default.
• W2000744122 cites W1603274157 @default.
• W2000744122 cites W1966117168 @default.
• W2000744122 cites W1969875513 @default.
• W2000744122 cites W1970613671 @default.
• W2000744122 cites W1971552869 @default.
• W2000744122 cites W1972513389 @default.
• W2000744122 cites W1973228989 @default.
• W2000744122 cites W1973739813 @default.
• W2000744122 cites W1974365812 @default.
• W2000744122 cites W1974385832 @default.
• W2000744122 cites W1975641514 @default.
• W2000744122 cites W1975691556 @default.
• W2000744122 cites W1978310995 @default.
• W2000744122 cites W1980826665 @default.
• W2000744122 cites W1983371169 @default.
• W2000744122 cites W1985048337 @default.
• W2000744122 cites W1988477436 @default.
• W2000744122 cites W1997340548 @default.
• W2000744122 cites W1999561809 @default.
• W2000744122 cites W2006998486 @default.
• W2000744122 cites W2010829954 @default.
• W2000744122 cites W2011033953 @default.
• W2000744122 cites W2011522291 @default.
• W2000744122 cites W2020125455 @default.
• W2000744122 cites W2020601776 @default.
• W2000744122 cites W2031363100 @default.
• W2000744122 cites W2044775747 @default.
• W2000744122 cites W2047567287 @default.
• W2000744122 cites W2049617698 @default.
• W2000744122 cites W2053071903 @default.
• W2000744122 cites W2053549636 @default.
• W2000744122 cites W2057335633 @default.
• W2000744122 cites W2057846043 @default.
• W2000744122 cites W2060754823 @default.
• W2000744122 cites W2061750520 @default.
• W2000744122 cites W2063273962 @default.
• W2000744122 cites W2065868638 @default.
• W2000744122 cites W2066558945 @default.
• W2000744122 cites W2067265489 @default.
• W2000744122 cites W2070354036 @default.
• W2000744122 cites W2073324778 @default.
• W2000744122 cites W2076959408 @default.
• W2000744122 cites W2077936290 @default.
• W2000744122 cites W2091468597 @default.
• W2000744122 cites W2094777850 @default.
• W2000744122 cites W2108281249 @default.
• W2000744122 cites W2111373319 @default.
• W2000744122 cites W2112482916 @default.
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• W2000744122 cites W2121473111 @default.
• W2000744122 cites W2130025497 @default.
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• W2000744122 cites W2131698520 @default.
• W2000744122 cites W2133402952 @default.
• W2000744122 cites W2136009931 @default.
• W2000744122 cites W2137092708 @default.
• W2000744122 cites W2137887442 @default.
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• W2000744122 cites W2145487150 @default.
• W2000744122 cites W2151301327 @default.
• W2000744122 cites W2156018434 @default.
• W2000744122 cites W2159718916 @default.
• W2000744122 cites W2160536323 @default.
• W2000744122 cites W2162109316 @default.
• W2000744122 cites W2167857702 @default.
• W2000744122 cites W2168002683 @default.
• W2000744122 cites W2168336490 @default.
• W2000744122 cites W2168833646 @default.
• W2000744122 cites W2320859155 @default.
• W2000744122 cites W2413436809 @default.
• W2000744122 cites W2418341685 @default.
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• W2000744122 doi "https://doi.org/10.1016/j.tips.2014.04.004" @default.
• W2000744122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24793542" @default.
• W2000744122 hasPublicationYear "2014" @default.
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