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• W2000744732 endingPage "452" @default.
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• W2000744732 abstract "Because NO is not very reactive in an oxygen-free buffer, a significant part of serotonin (5-HT) is transformed by NO in nondeaerated phosphate buffer, at pH 7.4, into (4-serotonyl)-4-serotonin, 4-nitrososerotonin, and 4-nitroserotonin. Dimerization and above all nitrosation occur through the HNO2 reaction in the pH 4-6 range, possibly via radical mechanism involving N2O3. 5-HT is readily a substrate for nitrosation by HNO2 or N2O3, whereas tyrosine was described as not very reactive under the same conditions. Peroxynitrite converts 5-HT to the (4-serotonyl)-4-serotonin and to the 4-nitro derivative. In order to evaluate whether such structural modifications could modulate the biological properties of 5-HT, arterial pressure was measured after i.v. bolus injection of these derivatives to anesthetized rats. Injections of the 4-nitroso- and 4-nitro-5-HT resulted in first a brief hypotensive response and did not give the subsequent hypertensive and hypotensive phases observed with 5-HT. Finally, when tested on some cloned rat 5-HT receptors stably transfected into LMTK- cells, both 4-nitroso and 4-nitro derivatives behaved as agonists and antagonists toward 5-HT1B and 5-HT2B receptors, respectively." @default.
• W2000744732 created "2016-06-24" @default.
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• W2000744732 date "1997-12-01" @default.
• W2000744732 modified "2023-10-18" @default.
• W2000744732 title "Oxidation, Nitrosation, and Nitration of Serotonin by Nitric Oxide-Derived Nitrogen Oxides: Biological Implications in the Rat Vascular System" @default.
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• W2000744732 doi "https://doi.org/10.1006/niox.1997.0147" @default.
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