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- W2000745834 abstract "Objectives To assess the severity and causes of inflammation of the gastric cardia in children undergoing endoscopy for symptoms of acid peptic disease. Study design Patients undergoing upper gastrointestinal endoscopy for symptoms of acid peptic disease had biopsies from gastric cardia, gastric, and esophageal sites, and 24-hour intraesophageal pH monitoring. Gastric cardia was defined at endoscopy as the anatomic zone from the squamocolumnar junction to 0.5 cm below it. Severity of gastric cardia inflammation was scored 0 to 9 according to densities of inflammatory cells and epithelial abnormalities in surface and pit epithelium. A score ≥2 was considered positive. Results Forty-seven children (median age, 6.5 years; range, 3–15) had Helicobacter pylori infection, gastroesophageal reflux disease (GERD), or both. In 22 patients, H pylori was detected in cardiac biopsies by rapid urease test and histology; it was detected also in the corpus and antrum in only seven of the 22. No patient had H pylori in gastric corpus/antrum without having the organism at the cardia as well. In 12 H pylori-positive patients, GERD was also diagnosed. Twenty-five patients had GERD and no H. pylori infection. Severity score was 3.8±0.8 in the H pylori group and 2.08±0.9 in the GERD alone group (P<.001); however, there was no difference in reflux index (24-hour % of gastroesophageal reflux) between the two groups. In neither group was correlation found between reflux index and severity score (H pylori, r = 0.22; GERD alone, r = 0.31; NS) nor between cardia inflammation and esophagitis grade (H pylori, r = 0.37; GERD alone, r = 0.22; NS). Conclusions In children with symptoms of acid peptic disease, inflammation of the gastric cardia does occur. It is more severe when the cardiac zone is infected with H pylori than in its absence. Of major practical significance is the finding that the gastric cardia is a highly sensitive site for the detection of H pylori infection." @default.
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- W2000745834 date "2003-10-01" @default.
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- W2000745834 title "Inflammation of the gastric cardia in children with symptoms of acid peptic disease" @default.
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- W2000745834 doi "https://doi.org/10.1067/s0022-3476(03)00392-5" @default.
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