FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000746048> ?p ?o ?g. }

• W2000746048 endingPage "5554" @default.
• W2000746048 startingPage "5544" @default.
• W2000746048 abstract "Abstract BACKGROUND: Among the treatment options that have been developed for cancer, chemotherapy remains 1 of the leading clinical approaches. Chemotherapy can usually control tumor growth at the onset of disease, but its effectiveness becomes limited by the overexpression of transporter proteins responsible for drug efflux, leading to multidrug resistance (MDR). To overcome this obstacle, the authors explored the feasibility of down‐regulating the main drug transporter, P‐glycoprotein (P‐gp), by using nonviral small interfering RNA (siRNA) delivery as means to enhance the accumulation of chemotherapeutic agents in drug‐resistant cancer cells. METHODS: Several cationic carriers capable of siRNA complexation were investigated for P‐gp down‐regulation in the MDA435/LCC6 cell line and, consequently, increased cellular uptake of the chemotherapeutic agents doxorubicin and paclitaxel. RESULTS: Efficient siRNA delivery into tumor cells was demonstrated particularly using a palmitic‐acid substituted poly(L‐lysine), with no apparent differences in siRNA delivery between the wild type (WT)‐expressing and P‐gp‐expressing phenotype (MDR1) of the cells. Efficient siRNA delivery led to approximately 40% to 50% P‐gp suppression (based on the average expression level of the protein), an approximately 3‐fold increased DOX uptake, and increased cytotoxicity in MDR1 cells. CONCLUSIONS: The authors concluded that effective siRNA delivery with nonviral carriers can reduce the level of P‐gp on cell surfaces and enhance the efficiency of chemotherapeutic agents in vitro. Cancer 2010. © 2010 American Cancer Society." @default.
• W2000746048 created "2016-06-24" @default.
• W2000746048 creator A5005848557 @default.
• W2000746048 creator A5014900225 @default.
• W2000746048 creator A5019819237 @default.
• W2000746048 creator A5044036955 @default.
• W2000746048 creator A5065812167 @default.
• W2000746048 date "2010-11-29" @default.
• W2000746048 modified "2023-10-15" @default.
• W2000746048 title "Cationic polymer-mediated small interfering RNA delivery for P-glycoprotein down-regulation in tumor cells" @default.
• W2000746048 cites W1545153134 @default.
• W2000746048 cites W1647075334 @default.
• W2000746048 cites W1964088888 @default.
• W2000746048 cites W1965727556 @default.
• W2000746048 cites W1973658117 @default.
• W2000746048 cites W1973855242 @default.
• W2000746048 cites W1977097370 @default.
• W2000746048 cites W1980435339 @default.
• W2000746048 cites W1980547595 @default.
• W2000746048 cites W1986547826 @default.
• W2000746048 cites W2006434892 @default.
• W2000746048 cites W2011742128 @default.
• W2000746048 cites W2021082805 @default.
• W2000746048 cites W2040837189 @default.
• W2000746048 cites W2049147399 @default.
• W2000746048 cites W2060711522 @default.
• W2000746048 cites W2071842134 @default.
• W2000746048 cites W2081722530 @default.
• W2000746048 cites W2083004369 @default.
• W2000746048 cites W2088391278 @default.
• W2000746048 cites W2088685757 @default.
• W2000746048 cites W2096619102 @default.
• W2000746048 cites W2101995865 @default.
• W2000746048 cites W2113657260 @default.
• W2000746048 cites W2145726831 @default.
• W2000746048 cites W2153175562 @default.
• W2000746048 cites W2169302611 @default.
• W2000746048 cites W4252592689 @default.
• W2000746048 cites W4254787154 @default.
• W2000746048 doi "https://doi.org/10.1002/cncr.25321" @default.
• W2000746048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20715163" @default.
• W2000746048 hasPublicationYear "2010" @default.
• W2000746048 type Work @default.
• W2000746048 sameAs 2000746048 @default.
• W2000746048 citedByCount "35" @default.
• W2000746048 countsByYear W20007460482012 @default.
• W2000746048 countsByYear W20007460482013 @default.
• W2000746048 countsByYear W20007460482014 @default.
• W2000746048 countsByYear W20007460482015 @default.
• W2000746048 countsByYear W20007460482016 @default.
• W2000746048 countsByYear W20007460482017 @default.
• W2000746048 countsByYear W20007460482018 @default.
• W2000746048 countsByYear W20007460482019 @default.
• W2000746048 crossrefType "journal-article" @default.
• W2000746048 hasAuthorship W2000746048A5005848557 @default.
• W2000746048 hasAuthorship W2000746048A5014900225 @default.
• W2000746048 hasAuthorship W2000746048A5019819237 @default.
• W2000746048 hasAuthorship W2000746048A5044036955 @default.
• W2000746048 hasAuthorship W2000746048A5065812167 @default.
• W2000746048 hasBestOaLocation W20007460481 @default.
• W2000746048 hasConcept C104317684 @default.
• W2000746048 hasConcept C109316439 @default.
• W2000746048 hasConcept C114851261 @default.
• W2000746048 hasConcept C119056186 @default.
• W2000746048 hasConcept C121608353 @default.
• W2000746048 hasConcept C126322002 @default.
• W2000746048 hasConcept C133936738 @default.
• W2000746048 hasConcept C166703698 @default.
• W2000746048 hasConcept C178790620 @default.
• W2000746048 hasConcept C185592680 @default.
• W2000746048 hasConcept C202751555 @default.
• W2000746048 hasConcept C22615655 @default.
• W2000746048 hasConcept C2776694085 @default.
• W2000746048 hasConcept C2777292972 @default.
• W2000746048 hasConcept C2778707650 @default.
• W2000746048 hasConcept C2779820397 @default.
• W2000746048 hasConcept C2781303535 @default.
• W2000746048 hasConcept C502942594 @default.
• W2000746048 hasConcept C54009773 @default.
• W2000746048 hasConcept C54355233 @default.
• W2000746048 hasConcept C55493867 @default.
• W2000746048 hasConcept C67705224 @default.
• W2000746048 hasConcept C71924100 @default.
• W2000746048 hasConcept C81885089 @default.
• W2000746048 hasConcept C86803240 @default.
• W2000746048 hasConcept C89423630 @default.
• W2000746048 hasConcept C96232424 @default.
• W2000746048 hasConcept C98274493 @default.
• W2000746048 hasConceptScore W2000746048C104317684 @default.
• W2000746048 hasConceptScore W2000746048C109316439 @default.
• W2000746048 hasConceptScore W2000746048C114851261 @default.
• W2000746048 hasConceptScore W2000746048C119056186 @default.
• W2000746048 hasConceptScore W2000746048C121608353 @default.
• W2000746048 hasConceptScore W2000746048C126322002 @default.
• W2000746048 hasConceptScore W2000746048C133936738 @default.
• W2000746048 hasConceptScore W2000746048C166703698 @default.
• W2000746048 hasConceptScore W2000746048C178790620 @default.
• W2000746048 hasConceptScore W2000746048C185592680 @default.

• next