FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000746537> ?p ?o ?g. }

• W2000746537 endingPage "1574" @default.
• W2000746537 startingPage "1564" @default.
• W2000746537 abstract "Bronchiolitis obliterans is the leading cause of chronic graft failure and long-term mortality in lung transplant recipients. Here, we used a novel murine model to characterize allograft fibrogenesis within a whole-lung microenvironment. Unilateral left lung transplantation was performed in mice across varying degrees of major histocompatibility complex mismatch combinations. B6D2F1/J (a cross between C57BL/6J and DBA/2J) (Haplotype H2b/d) lungs transplanted into DBA/2J (H2d) recipients were identified to show histopathology for bronchiolitis obliterans in all allogeneic grafts. Time course analysis showed an evolution from immune cell infiltration of the bronchioles and vessels at day 14, consistent with acute rejection and lymphocytic bronchitis, to subepithelial and intraluminal fibrotic lesions of bronchiolitis obliterans by day 28. Allografts at day 28 showed a significantly higher hydroxyproline content than the isografts (33.21 ± 1.89 versus 22.36 ± 2.33 μg/mL). At day 40 the hydroxyproline content had increased further (48.91 ± 7.09 μg/mL). Flow cytometric analysis was used to investigate the origin of mesenchymal cells in fibrotic allografts. Collagen I-positive cells (89.43% ± 6.53%) in day 28 allografts were H2Db positive, showing their donor origin. This novel murine model shows consistent and reproducible allograft fibrogenesis in the context of single-lung transplantation and represents a major step forward in investigating mechanisms of chronic graft failure." @default.
• W2000746537 created "2016-06-24" @default.
• W2000746537 creator A5011243725 @default.
• W2000746537 creator A5027006001 @default.
• W2000746537 creator A5034466923 @default.
• W2000746537 creator A5037153658 @default.
• W2000746537 creator A5039544059 @default.
• W2000746537 creator A5044612647 @default.
• W2000746537 creator A5060706289 @default.
• W2000746537 creator A5063512974 @default.
• W2000746537 creator A5077814859 @default.
• W2000746537 date "2015-06-01" @default.
• W2000746537 modified "2023-10-17" @default.
• W2000746537 title "Local Origin of Mesenchymal Cells in a Murine Orthotopic Lung Transplantation Model of Bronchiolitis Obliterans" @default.
• W2000746537 cites W132663712 @default.
• W2000746537 cites W134164392 @default.
• W2000746537 cites W1487373628 @default.
• W2000746537 cites W1492318430 @default.
• W2000746537 cites W1492928557 @default.
• W2000746537 cites W1505584712 @default.
• W2000746537 cites W1527854766 @default.
• W2000746537 cites W1589219478 @default.
• W2000746537 cites W1602738207 @default.
• W2000746537 cites W180714979 @default.
• W2000746537 cites W1971533405 @default.
• W2000746537 cites W1972590847 @default.
• W2000746537 cites W1974778378 @default.
• W2000746537 cites W1988738629 @default.
• W2000746537 cites W1990268016 @default.
• W2000746537 cites W1995646773 @default.
• W2000746537 cites W1998754138 @default.
• W2000746537 cites W2002323163 @default.
• W2000746537 cites W2006196877 @default.
• W2000746537 cites W2006323392 @default.
• W2000746537 cites W2011415380 @default.
• W2000746537 cites W2013426785 @default.
• W2000746537 cites W2023919621 @default.
• W2000746537 cites W2033383767 @default.
• W2000746537 cites W2036316606 @default.
• W2000746537 cites W2037419643 @default.
• W2000746537 cites W2037537803 @default.
• W2000746537 cites W2039688361 @default.
• W2000746537 cites W2040767465 @default.
• W2000746537 cites W2042030389 @default.
• W2000746537 cites W2042976227 @default.
• W2000746537 cites W2043478495 @default.
• W2000746537 cites W2053896124 @default.
• W2000746537 cites W2054294447 @default.
• W2000746537 cites W2060468723 @default.
• W2000746537 cites W2067299229 @default.
• W2000746537 cites W2071131004 @default.
• W2000746537 cites W2076519595 @default.
• W2000746537 cites W2077936953 @default.
• W2000746537 cites W2078953642 @default.
• W2000746537 cites W2081710302 @default.
• W2000746537 cites W2088260073 @default.
• W2000746537 cites W2094548571 @default.
• W2000746537 cites W2105949004 @default.
• W2000746537 cites W2114674572 @default.
• W2000746537 cites W2121895557 @default.
• W2000746537 cites W2132227824 @default.
• W2000746537 cites W2134277886 @default.
• W2000746537 cites W2134764292 @default.
• W2000746537 cites W2143265118 @default.
• W2000746537 cites W2145466675 @default.
• W2000746537 cites W2159999899 @default.
• W2000746537 cites W2160202789 @default.
• W2000746537 cites W2161412220 @default.
• W2000746537 cites W2165787419 @default.
• W2000746537 cites W2166123227 @default.
• W2000746537 cites W2397725176 @default.
• W2000746537 cites W4238650021 @default.
• W2000746537 doi "https://doi.org/10.1016/j.ajpath.2015.03.002" @default.
• W2000746537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4450312" @default.
• W2000746537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25848843" @default.
• W2000746537 hasPublicationYear "2015" @default.
• W2000746537 type Work @default.
• W2000746537 sameAs 2000746537 @default.
• W2000746537 citedByCount "26" @default.
• W2000746537 countsByYear W20007465372016 @default.
• W2000746537 countsByYear W20007465372017 @default.
• W2000746537 countsByYear W20007465372018 @default.
• W2000746537 countsByYear W20007465372019 @default.
• W2000746537 countsByYear W20007465372020 @default.
• W2000746537 countsByYear W20007465372021 @default.
• W2000746537 countsByYear W20007465372022 @default.
• W2000746537 countsByYear W20007465372023 @default.
• W2000746537 crossrefType "journal-article" @default.
• W2000746537 hasAuthorship W2000746537A5011243725 @default.
• W2000746537 hasAuthorship W2000746537A5027006001 @default.
• W2000746537 hasAuthorship W2000746537A5034466923 @default.
• W2000746537 hasAuthorship W2000746537A5037153658 @default.
• W2000746537 hasAuthorship W2000746537A5039544059 @default.
• W2000746537 hasAuthorship W2000746537A5044612647 @default.
• W2000746537 hasAuthorship W2000746537A5060706289 @default.
• W2000746537 hasAuthorship W2000746537A5063512974 @default.
• W2000746537 hasAuthorship W2000746537A5077814859 @default.
• W2000746537 hasBestOaLocation W20007465371 @default.

• next