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- W2000746599 abstract "Periportal and perivenous hepatocytes differ in their metabolism of blood glutamate (Glu). Uncertainty about the mechanisms of Glu blood-liver exchange led us to characterise, by paired-tracer dilution, a sodium-dependent dicarboxylate transporter (resembling system X-ag) in sinusoidal membranes of perfused rat liver (Vmax = 0.18 mumol Glu/g per min, Km = 0.29 mM Glu). Tracer Glu transport was depressed 65% after necrosis of perivenous hepatocytes by acute CCl4 treatment, indicating that X-ag transporter activity is located mainly in these cells, the sites of glutamine (Gln) synthesis from glutamate and ammonia. Modulation of Glu transport may influence the extent of hepatic Gln release." @default.
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- W2000746599 date "1987-09-14" @default.
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- W2000746599 title "Perivenous localisation of Na-dependent glutamate transport in perfused rat liver" @default.
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- W2000746599 doi "https://doi.org/10.1016/0014-5793(87)80958-4" @default.
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