FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000747219> ?p ?o ?g. }

• W2000747219 endingPage "197" @default.
• W2000747219 startingPage "187" @default.
• W2000747219 abstract "Since CD28 costimulation is critical for T-cell activation, there is great interest in CD28 as a target for immuntherapeutic approaches. We show that stimulation of human CD4(+) and CD8(+) T-cells differs in their responsiveness to stimulation with anti-CD3/CD28-coated beads, as surrogate antigen-presenting cells. While the CD4(+) subset responded with sustained proliferation, CD8(+) T-cells grew for a limited period only and failed to produce IL-2 beyond the first few days in culture. This decrease is accompanied with an increased rate of apoptosis in CD8(+) T-cells despite Bcl-x(L) expression. The CD8(+) but not the CD4(+) subset developed a reversible double-positive phenotype during CD28 costimulation. This finding may have some bearing on the appearance of double-positive T-cells in human peripheral blood. This double-positive subset was shown to undergo a statistically significantly increase during aging in humans. Taken together, the above data have important implications for immunotherapy and immune senescence." @default.
• W2000747219 created "2016-06-24" @default.
• W2000747219 creator A5008558372 @default.
• W2000747219 creator A5012362668 @default.
• W2000747219 creator A5012688898 @default.
• W2000747219 creator A5029600225 @default.
• W2000747219 creator A5060212240 @default.
• W2000747219 creator A5067067769 @default.
• W2000747219 creator A5071035545 @default.
• W2000747219 creator A5075548630 @default.
• W2000747219 date "2000-09-01" @default.
• W2000747219 modified "2023-10-03" @default.
• W2000747219 title "Response Differences between Human CD4+ and CD8+ T-Cells during CD28 Costimulation: Implications for Immune Cell-Based Therapies and Studies Related to the Expansion of Double-Positive T-Cells during Aging" @default.
• W2000747219 cites W1481172479 @default.
• W2000747219 cites W1488633968 @default.
• W2000747219 cites W1510990767 @default.
• W2000747219 cites W1537606049 @default.
• W2000747219 cites W1559378051 @default.
• W2000747219 cites W1563876646 @default.
• W2000747219 cites W1570667844 @default.
• W2000747219 cites W1592074867 @default.
• W2000747219 cites W1610777332 @default.
• W2000747219 cites W1660737759 @default.
• W2000747219 cites W1810174285 @default.
• W2000747219 cites W1839771299 @default.
• W2000747219 cites W1899646506 @default.
• W2000747219 cites W1930345819 @default.
• W2000747219 cites W1968102829 @default.
• W2000747219 cites W1970581527 @default.
• W2000747219 cites W1975999249 @default.
• W2000747219 cites W1982538054 @default.
• W2000747219 cites W2009014910 @default.
• W2000747219 cites W2011326882 @default.
• W2000747219 cites W2030709286 @default.
• W2000747219 cites W2040852036 @default.
• W2000747219 cites W2041356194 @default.
• W2000747219 cites W2044246857 @default.
• W2000747219 cites W2045843248 @default.
• W2000747219 cites W2050428842 @default.
• W2000747219 cites W2054419682 @default.
• W2000747219 cites W2061604045 @default.
• W2000747219 cites W2062994475 @default.
• W2000747219 cites W2063366670 @default.
• W2000747219 cites W2072858020 @default.
• W2000747219 cites W2081185044 @default.
• W2000747219 cites W2081833011 @default.
• W2000747219 cites W2082048091 @default.
• W2000747219 cites W2086546074 @default.
• W2000747219 cites W2086776723 @default.
• W2000747219 cites W2090867462 @default.
• W2000747219 cites W2091783976 @default.
• W2000747219 cites W2100689227 @default.
• W2000747219 cites W2121230396 @default.
• W2000747219 cites W2124198363 @default.
• W2000747219 cites W2127387126 @default.
• W2000747219 cites W2134879627 @default.
• W2000747219 cites W2143381632 @default.
• W2000747219 cites W2146958759 @default.
• W2000747219 cites W2155025120 @default.
• W2000747219 cites W2157379528 @default.
• W2000747219 cites W2158017952 @default.
• W2000747219 cites W2298534373 @default.
• W2000747219 cites W4313333761 @default.
• W2000747219 cites W4313344477 @default.
• W2000747219 doi "https://doi.org/10.1006/clim.2000.4902" @default.
• W2000747219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10964536" @default.
• W2000747219 hasPublicationYear "2000" @default.
• W2000747219 type Work @default.
• W2000747219 sameAs 2000747219 @default.
• W2000747219 citedByCount "80" @default.
• W2000747219 countsByYear W20007472192013 @default.
• W2000747219 countsByYear W20007472192014 @default.
• W2000747219 countsByYear W20007472192015 @default.
• W2000747219 countsByYear W20007472192017 @default.
• W2000747219 countsByYear W20007472192018 @default.
• W2000747219 countsByYear W20007472192019 @default.
• W2000747219 countsByYear W20007472192020 @default.
• W2000747219 countsByYear W20007472192021 @default.
• W2000747219 countsByYear W20007472192022 @default.
• W2000747219 countsByYear W20007472192023 @default.
• W2000747219 crossrefType "journal-article" @default.
• W2000747219 hasAuthorship W2000747219A5008558372 @default.
• W2000747219 hasAuthorship W2000747219A5012362668 @default.
• W2000747219 hasAuthorship W2000747219A5012688898 @default.
• W2000747219 hasAuthorship W2000747219A5029600225 @default.
• W2000747219 hasAuthorship W2000747219A5060212240 @default.
• W2000747219 hasAuthorship W2000747219A5067067769 @default.
• W2000747219 hasAuthorship W2000747219A5071035545 @default.
• W2000747219 hasAuthorship W2000747219A5075548630 @default.
• W2000747219 hasConcept C148125776 @default.
• W2000747219 hasConcept C154317977 @default.
• W2000747219 hasConcept C167672396 @default.
• W2000747219 hasConcept C202751555 @default.
• W2000747219 hasConcept C203014093 @default.
• W2000747219 hasConcept C2776090121 @default.
• W2000747219 hasConcept C2777701055 @default.
• W2000747219 hasConcept C502942594 @default.
• W2000747219 hasConcept C522857546 @default.

• next