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• W2000747235 endingPage "105" @default.
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• W2000747235 abstract "Animal studies on inner ear development, repair and regeneration provide understanding of molecular pathways that can be harnessed for treating inner ear disease. Use of transgenic mouse technology, in particular, has contributed knowledge of genes that regulate development of hair cells and innervation, and of molecular players that can induce regeneration, but this technology is not applicable for human treatment, for practical and ethical reasons. Therefore other means for influencing gene expression in the inner ear are needed. We describe several gene vectors useful for inner ear gene therapy and the practical aspects of introducing these vectors into the ear. We then review the progress toward using gene transfer for therapies in both auditory and balance systems, and discuss the technological milestones needed to advance to clinical application of these methods." @default.
• W2000747235 created "2016-06-24" @default.
• W2000747235 creator A5001201586 @default.
• W2000747235 creator A5052579903 @default.
• W2000747235 date "2013-03-01" @default.
• W2000747235 modified "2023-09-23" @default.
• W2000747235 title "Gene therapy for the inner ear" @default.
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• W2000747235 doi "https://doi.org/10.1016/j.heares.2012.11.017" @default.
• W2000747235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3594056" @default.
• W2000747235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23265411" @default.
• W2000747235 hasPublicationYear "2013" @default.
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