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- W2000747883 abstract "Observational studies have provided evidence that a consistent fraction (approximately 15–20%) of hypertensive patients displays a glucose intolerance state that may be aggravated by antihypertensive drug regimens based on thiazide diuretics or beta-blockers. This review examines the relative and absolute diabetogenic effects of antihypertensive drugs, by comparing the impact of ‘new’ (calcium antagonists, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists) versus ‘old’ (diuretics and beta-blockers) drugs on new-onset diabetes in recent clinical trials. Evidence is provided that compared with diuretics and beta-blockers, new-onset diabetes is less common with ‘new’ drugs, and that conventional antihypertensive compounds, particularly when combined together, may amplify the natural time-dependent tendency towards the development of this metabolic disease. This paper provides new insights into the potential mechanisms responsible for the phenomenon and the clinical significance of antihypertensive drug-induced diabetes." @default.
- W2000747883 created "2016-06-24" @default.
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- W2000747883 date "2006-01-01" @default.
- W2000747883 modified "2023-10-12" @default.
- W2000747883 title "New-onset diabetes and antihypertensive drugs" @default.
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- W2000747883 doi "https://doi.org/10.1097/01.hjh.0000194119.42722.21" @default.
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