Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000748318> ?p ?o ?g. }
- W2000748318 endingPage "1830" @default.
- W2000748318 startingPage "1823" @default.
- W2000748318 abstract "IgG Fc receptors (FcgammaRs, especially FcgammaRIII) and complement (in particular, C5a anaphylatoxin) are critical effectors of the acute inflammatory response to immune complexes (ICs). However, it is unknown whether and how these two key components can interact with each other in vivo. We use here a mouse model of the acute pulmonary IC hypersensitivity reaction to analyze their potential interaction. FcgammaRIII and C5aR are coexpressed on alveolar macrophages (AMs), and both FcgammaRIII and C5aR mutant mice display impaired immune responses. We find that recombinant human C5a (rhC5a) can control inverse expression of various FcgammaRs, and costimulation of ICs with rhC5a results in strong enhancement of FcgammaRIII-triggered cellular activation in vitro and in vivo. Moreover, we show here that early IC-induced bioactive C5a, and its interaction with C5aR, causes induction of activating FcgammaRIII and suppression of inhibitory FcgammaRII on AMs that appears crucial for efficient cytokine production and neutrophil recruitment in lung pathology. Therefore, C5a, which is a potent chemoattractant, has a broader critical function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation." @default.
- W2000748318 created "2016-06-24" @default.
- W2000748318 creator A5012844484 @default.
- W2000748318 creator A5028557050 @default.
- W2000748318 creator A5036911759 @default.
- W2000748318 creator A5042237095 @default.
- W2000748318 creator A5049382632 @default.
- W2000748318 creator A5049525272 @default.
- W2000748318 creator A5050909614 @default.
- W2000748318 date "2002-12-15" @default.
- W2000748318 modified "2023-10-16" @default.
- W2000748318 title "C5a anaphylatoxin is a major regulator of activating versus inhibitory FcγRs in immune complex–induced lung disease" @default.
- W2000748318 cites W136158069 @default.
- W2000748318 cites W1452338814 @default.
- W2000748318 cites W1502023852 @default.
- W2000748318 cites W1507839987 @default.
- W2000748318 cites W1555703707 @default.
- W2000748318 cites W1573885922 @default.
- W2000748318 cites W1583599993 @default.
- W2000748318 cites W1644900513 @default.
- W2000748318 cites W1864540175 @default.
- W2000748318 cites W1882029866 @default.
- W2000748318 cites W1882263729 @default.
- W2000748318 cites W1903287340 @default.
- W2000748318 cites W1930438092 @default.
- W2000748318 cites W193927762 @default.
- W2000748318 cites W1968544303 @default.
- W2000748318 cites W1972108403 @default.
- W2000748318 cites W1973284569 @default.
- W2000748318 cites W1977090347 @default.
- W2000748318 cites W1977631644 @default.
- W2000748318 cites W1983301902 @default.
- W2000748318 cites W1983940041 @default.
- W2000748318 cites W1995016243 @default.
- W2000748318 cites W2002411614 @default.
- W2000748318 cites W2003590292 @default.
- W2000748318 cites W2033376136 @default.
- W2000748318 cites W2048106753 @default.
- W2000748318 cites W2053246714 @default.
- W2000748318 cites W2054080837 @default.
- W2000748318 cites W2058071683 @default.
- W2000748318 cites W2058757949 @default.
- W2000748318 cites W2064681913 @default.
- W2000748318 cites W2079292781 @default.
- W2000748318 cites W2098240796 @default.
- W2000748318 cites W2098788256 @default.
- W2000748318 cites W2123430087 @default.
- W2000748318 cites W2134941921 @default.
- W2000748318 cites W2141962108 @default.
- W2000748318 cites W2147306445 @default.
- W2000748318 cites W2148706075 @default.
- W2000748318 cites W2149103649 @default.
- W2000748318 cites W2151486736 @default.
- W2000748318 cites W2159549182 @default.
- W2000748318 cites W2166874143 @default.
- W2000748318 cites W2169965373 @default.
- W2000748318 cites W4235898601 @default.
- W2000748318 cites W4236183098 @default.
- W2000748318 cites W4241518199 @default.
- W2000748318 doi "https://doi.org/10.1172/jci16577" @default.
- W2000748318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/151656" @default.
- W2000748318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12488432" @default.
- W2000748318 hasPublicationYear "2002" @default.
- W2000748318 type Work @default.
- W2000748318 sameAs 2000748318 @default.
- W2000748318 citedByCount "267" @default.
- W2000748318 countsByYear W20007483182012 @default.
- W2000748318 countsByYear W20007483182013 @default.
- W2000748318 countsByYear W20007483182014 @default.
- W2000748318 countsByYear W20007483182015 @default.
- W2000748318 countsByYear W20007483182016 @default.
- W2000748318 countsByYear W20007483182017 @default.
- W2000748318 countsByYear W20007483182018 @default.
- W2000748318 countsByYear W20007483182019 @default.
- W2000748318 countsByYear W20007483182020 @default.
- W2000748318 countsByYear W20007483182021 @default.
- W2000748318 countsByYear W20007483182022 @default.
- W2000748318 countsByYear W20007483182023 @default.
- W2000748318 crossrefType "journal-article" @default.
- W2000748318 hasAuthorship W2000748318A5012844484 @default.
- W2000748318 hasAuthorship W2000748318A5028557050 @default.
- W2000748318 hasAuthorship W2000748318A5036911759 @default.
- W2000748318 hasAuthorship W2000748318A5042237095 @default.
- W2000748318 hasAuthorship W2000748318A5049382632 @default.
- W2000748318 hasAuthorship W2000748318A5049525272 @default.
- W2000748318 hasAuthorship W2000748318A5050909614 @default.
- W2000748318 hasBestOaLocation W20007483181 @default.
- W2000748318 hasConcept C111684460 @default.
- W2000748318 hasConcept C170493617 @default.
- W2000748318 hasConcept C175773311 @default.
- W2000748318 hasConcept C203014093 @default.
- W2000748318 hasConcept C207001950 @default.
- W2000748318 hasConcept C2776914184 @default.
- W2000748318 hasConcept C2779499704 @default.
- W2000748318 hasConcept C51785407 @default.
- W2000748318 hasConcept C54355233 @default.
- W2000748318 hasConcept C71318922 @default.
- W2000748318 hasConcept C86803240 @default.