Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000749502> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2000749502 endingPage "1088" @default.
- W2000749502 startingPage "1070" @default.
- W2000749502 abstract "An efficient, isocratic, reversed-phase high performance liquid chromatography method was developed, optimized, and validated to separate nine antihypertensive drugs by experimental design methodology and the Crossed D-Optimal process. In order to find the most suitable separation conditions, twenty-three experiments were carried out, based on the simultaneous effects of three solvent (methanol, acetonitrile, and water) compositions in combination with different pH values of the mobile phase. The components were cross-combined with a pH factor (quadratic x quadratic process), whereas optimal adjusted models were used for the eight individually chosen responses. The optimal mobile phase consisted of methanol, acetonitrile, and 0.05 M aqueous ammonium acetate at pH 3.1 (18:26: 56 v/v/v, pH adjustment with formic acid). Analysis was carried out on a C18 column (150 × 4.6 mm, 5 µm) at 40 °C using photodiode array detection at 242 nm. The system was found to produce sharp and well resolved peaks for all analytes while the retention times ranged from 2.3 to 31 min. The method was linear (r2 > 0.999) and reliable since the accuracy (recovery = 100 ± 2.9) and the precision (relative standard deviation < 2%) met International Conference on Harmonization guidelines. The technique was shown to be a useful tool for separating complex mixtures using experimental design methodology." @default.
- W2000749502 created "2016-06-24" @default.
- W2000749502 creator A5011028952 @default.
- W2000749502 creator A5089576254 @default.
- W2000749502 date "2015-02-09" @default.
- W2000749502 modified "2023-09-24" @default.
- W2000749502 title "Crossed D-Optimal Experimental Design Methodology for the Chromatographic Separation of Antihypertensive Drugs" @default.
- W2000749502 cites W1976332112 @default.
- W2000749502 cites W1985208185 @default.
- W2000749502 cites W1986159254 @default.
- W2000749502 cites W1988784507 @default.
- W2000749502 cites W1993163601 @default.
- W2000749502 cites W2001499615 @default.
- W2000749502 cites W2009824338 @default.
- W2000749502 cites W2012671010 @default.
- W2000749502 cites W2014938147 @default.
- W2000749502 cites W2029392196 @default.
- W2000749502 cites W2063297587 @default.
- W2000749502 cites W2093756873 @default.
- W2000749502 cites W2094507385 @default.
- W2000749502 cites W2101523886 @default.
- W2000749502 cites W2105870008 @default.
- W2000749502 cites W2106382672 @default.
- W2000749502 cites W2109529773 @default.
- W2000749502 cites W2130536685 @default.
- W2000749502 cites W2164860407 @default.
- W2000749502 cites W2232931138 @default.
- W2000749502 cites W4243553261 @default.
- W2000749502 doi "https://doi.org/10.1080/00032719.2014.976870" @default.
- W2000749502 hasPublicationYear "2015" @default.
- W2000749502 type Work @default.
- W2000749502 sameAs 2000749502 @default.
- W2000749502 citedByCount "1" @default.
- W2000749502 countsByYear W20007495022021 @default.
- W2000749502 crossrefType "journal-article" @default.
- W2000749502 hasAuthorship W2000749502A5011028952 @default.
- W2000749502 hasAuthorship W2000749502A5089576254 @default.
- W2000749502 hasConcept C10390740 @default.
- W2000749502 hasConcept C113196181 @default.
- W2000749502 hasConcept C178790620 @default.
- W2000749502 hasConcept C179998833 @default.
- W2000749502 hasConcept C185592680 @default.
- W2000749502 hasConcept C2777379063 @default.
- W2000749502 hasConcept C2777463227 @default.
- W2000749502 hasConcept C2779607525 @default.
- W2000749502 hasConcept C2780782300 @default.
- W2000749502 hasConcept C43617362 @default.
- W2000749502 hasConcept C4725764 @default.
- W2000749502 hasConceptScore W2000749502C10390740 @default.
- W2000749502 hasConceptScore W2000749502C113196181 @default.
- W2000749502 hasConceptScore W2000749502C178790620 @default.
- W2000749502 hasConceptScore W2000749502C179998833 @default.
- W2000749502 hasConceptScore W2000749502C185592680 @default.
- W2000749502 hasConceptScore W2000749502C2777379063 @default.
- W2000749502 hasConceptScore W2000749502C2777463227 @default.
- W2000749502 hasConceptScore W2000749502C2779607525 @default.
- W2000749502 hasConceptScore W2000749502C2780782300 @default.
- W2000749502 hasConceptScore W2000749502C43617362 @default.
- W2000749502 hasConceptScore W2000749502C4725764 @default.
- W2000749502 hasIssue "7" @default.
- W2000749502 hasLocation W20007495021 @default.
- W2000749502 hasOpenAccess W2000749502 @default.
- W2000749502 hasPrimaryLocation W20007495021 @default.
- W2000749502 hasRelatedWork W1964888264 @default.
- W2000749502 hasRelatedWork W2043512602 @default.
- W2000749502 hasRelatedWork W2074088656 @default.
- W2000749502 hasRelatedWork W2077423873 @default.
- W2000749502 hasRelatedWork W2361276660 @default.
- W2000749502 hasRelatedWork W2376531500 @default.
- W2000749502 hasRelatedWork W2379011834 @default.
- W2000749502 hasRelatedWork W2394307646 @default.
- W2000749502 hasRelatedWork W2800075672 @default.
- W2000749502 hasRelatedWork W2949932373 @default.
- W2000749502 hasVolume "48" @default.
- W2000749502 isParatext "false" @default.
- W2000749502 isRetracted "false" @default.
- W2000749502 magId "2000749502" @default.
- W2000749502 workType "article" @default.