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- W2000749702 abstract "Purpose of review There has been significant progress in our understanding of the structural and functional properties and regulation of the electrogenic Na+-base transporter NBCe1, a membrane transporter that plays a key role in renal acid–base physiology. The NBCe1 variant NBCe1-A mediates basolateral electrogenic Na+-base transport in the proximal tubule and is critically required for transepithelial bicarbonate absorption. Mutations in NBCe1 cause autosomal recessive proximal renal tubular acidosis (pRTA). The review summarizes recent advances in this area. Recent findings A topological model of NBCe1 has been established that provides a foundation for future structure-functional studies of the transporter. Critical residues and regions have been identified in NBCe1 that play key roles in its structure, function (substrate transport, electrogenicity) and regulation. The mechanisms of how NBCe1 mutations cause pRTA have also recently been elucidated. Summary Given the important role of proximal tubule transepithelial bicarbonate absorption in systemic acid–base balance, a clear understanding of the structure–functional properties of NBCe1 is a prerequisite for elucidating the mechanisms of defective transepithelial bicarbonate transport in pRTA." @default.
- W2000749702 created "2016-06-24" @default.
- W2000749702 creator A5006549974 @default.
- W2000749702 creator A5048085772 @default.
- W2000749702 date "2013-09-01" @default.
- W2000749702 modified "2023-09-23" @default.
- W2000749702 title "Structure, function, and regulation of the SLC4 NBCe1 transporter and its role in causing proximal renal tubular acidosis" @default.
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- W2000749702 doi "https://doi.org/10.1097/mnh.0b013e328363ff43" @default.
- W2000749702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4132186" @default.
- W2000749702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23917030" @default.
- W2000749702 hasPublicationYear "2013" @default.
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