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• W2000751446 abstract "Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal.Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]).Adoptive transfer of ex vivo activated alloreactive host T cells (aHLI) led to the control and complete resolution of severe GvHD without inducing allograft rejection.aHLI opens a novel therapeutic window to control solid-organ transplant-associated GvHD while preserving allograft integrity." @default.
• W2000751446 created "2016-06-24" @default.
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• W2000751446 date "2004-12-01" @default.
• W2000751446 modified "2023-10-05" @default.
• W2000751446 title "Control Of Organ Transplant-Associated Graft-versus-Host Disease By Activated Host Lymphocyte Infusions" @default.
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• W2000751446 doi "https://doi.org/10.1097/01.tp.0000144183.77279.ec" @default.
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