FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000751577> ?p ?o ?g. }

• W2000751577 endingPage "115" @default.
• W2000751577 startingPage "108" @default.
• W2000751577 abstract "Data from a phase II trial combining chemoradiotherapy with IFN-alpha (CapRI scheme) for adjuvant treatment of pancreatic carcinoma are very encouraging. Therefore, a phase III trial comparing chemotherapy with the chemoradiotherapy with IFN-alpha scheme has been initiated in August 2004. Translational research with a focus on immunomodulation is performed in parallel to the study. Blood and serum samples are taken at various time points. Patients in arm A (chemoradioimmunotherapy) receive a single low-dose-Interferon injection before therapy to investigate the direct effect of IFN-alpha. So far samples from 44 patients have been investigated for surface molecule expression, cytokine levels, natural killer cell cytotoxicity, and antigen-specific Granzyme B release. Patients in arm A showed 1 day after IFN-alpha injection a significant increase in spontaneous cytotoxicity; this effect was fading after repeated injections. Furthermore, cells releasing Granzyme B after stimulation with CA 19.9 and MUC-1 protein increased under therapy. Five days after the first IFN-alpha injection, IL-12 and TNF-alpha serum levels peak. We observed significant increases of monocytes, peripheral dendritic cells, CD40 cells, central and effector memory T cells, and CD8 cells, CD4 cells decreased during therapy. All these effects were only observed in arm A patients and none of them in arm B patients. In conclusion, in a translational research project accompanying a challenging multimodality treatment trial including IFN-alpha, we observed an immediate activation of antigen-presenting cells and natural killer cells followed later on by antigen-specific activation. It will be most interesting if the immunologic data will show a correlation with the clinical course of the patients." @default.
• W2000751577 created "2016-06-24" @default.
• W2000751577 creator A5006080186 @default.
• W2000751577 creator A5006706914 @default.
• W2000751577 creator A5036032282 @default.
• W2000751577 creator A5041192788 @default.
• W2000751577 creator A5059278629 @default.
• W2000751577 date "2007-01-01" @default.
• W2000751577 modified "2023-09-23" @default.
• W2000751577 title "Impact of Interferon-α in Combined Chemoradioimmunotherapy for Pancreatic Adenocarcinoma (CapRI): First Data From the Immunomonitoring" @default.
• W2000751577 cites W1518090161 @default.
• W2000751577 cites W1522220290 @default.
• W2000751577 cites W1551136390 @default.
• W2000751577 cites W1782545213 @default.
• W2000751577 cites W1983923482 @default.
• W2000751577 cites W1999171100 @default.
• W2000751577 cites W2000786003 @default.
• W2000751577 cites W2006061341 @default.
• W2000751577 cites W2017449430 @default.
• W2000751577 cites W2038428454 @default.
• W2000751577 cites W2047318784 @default.
• W2000751577 cites W2071669054 @default.
• W2000751577 cites W2075256922 @default.
• W2000751577 cites W2091188319 @default.
• W2000751577 cites W2095198420 @default.
• W2000751577 cites W2098933955 @default.
• W2000751577 cites W2113180936 @default.
• W2000751577 cites W2134403422 @default.
• W2000751577 cites W2142908375 @default.
• W2000751577 cites W2144078346 @default.
• W2000751577 cites W2160236174 @default.
• W2000751577 cites W2186256429 @default.
• W2000751577 cites W2322032774 @default.
• W2000751577 doi "https://doi.org/10.1097/01.cji.0000211317.15278.27" @default.
• W2000751577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17198089" @default.
• W2000751577 hasPublicationYear "2007" @default.
• W2000751577 type Work @default.
• W2000751577 sameAs 2000751577 @default.
• W2000751577 citedByCount "33" @default.
• W2000751577 countsByYear W20007515772013 @default.
• W2000751577 countsByYear W20007515772014 @default.
• W2000751577 countsByYear W20007515772015 @default.
• W2000751577 countsByYear W20007515772016 @default.
• W2000751577 countsByYear W20007515772018 @default.
• W2000751577 countsByYear W20007515772019 @default.
• W2000751577 countsByYear W20007515772022 @default.
• W2000751577 crossrefType "journal-article" @default.
• W2000751577 hasAuthorship W2000751577A5006080186 @default.
• W2000751577 hasAuthorship W2000751577A5006706914 @default.
• W2000751577 hasAuthorship W2000751577A5036032282 @default.
• W2000751577 hasAuthorship W2000751577A5041192788 @default.
• W2000751577 hasAuthorship W2000751577A5059278629 @default.
• W2000751577 hasConcept C126322002 @default.
• W2000751577 hasConcept C147483822 @default.
• W2000751577 hasConcept C154317977 @default.
• W2000751577 hasConcept C167672396 @default.
• W2000751577 hasConcept C183193105 @default.
• W2000751577 hasConcept C185592680 @default.
• W2000751577 hasConcept C202751555 @default.
• W2000751577 hasConcept C203014093 @default.
• W2000751577 hasConcept C2776062744 @default.
• W2000751577 hasConcept C2777701055 @default.
• W2000751577 hasConcept C2777863537 @default.
• W2000751577 hasConcept C2780380082 @default.
• W2000751577 hasConcept C55493867 @default.
• W2000751577 hasConcept C71924100 @default.
• W2000751577 hasConcept C8891405 @default.
• W2000751577 hasConceptScore W2000751577C126322002 @default.
• W2000751577 hasConceptScore W2000751577C147483822 @default.
• W2000751577 hasConceptScore W2000751577C154317977 @default.
• W2000751577 hasConceptScore W2000751577C167672396 @default.
• W2000751577 hasConceptScore W2000751577C183193105 @default.
• W2000751577 hasConceptScore W2000751577C185592680 @default.
• W2000751577 hasConceptScore W2000751577C202751555 @default.
• W2000751577 hasConceptScore W2000751577C203014093 @default.
• W2000751577 hasConceptScore W2000751577C2776062744 @default.
• W2000751577 hasConceptScore W2000751577C2777701055 @default.
• W2000751577 hasConceptScore W2000751577C2777863537 @default.
• W2000751577 hasConceptScore W2000751577C2780380082 @default.
• W2000751577 hasConceptScore W2000751577C55493867 @default.
• W2000751577 hasConceptScore W2000751577C71924100 @default.
• W2000751577 hasConceptScore W2000751577C8891405 @default.
• W2000751577 hasIssue "1" @default.
• W2000751577 hasLocation W20007515771 @default.
• W2000751577 hasLocation W20007515772 @default.
• W2000751577 hasOpenAccess W2000751577 @default.
• W2000751577 hasPrimaryLocation W20007515771 @default.
• W2000751577 hasRelatedWork W1969504080 @default.
• W2000751577 hasRelatedWork W1983122232 @default.
• W2000751577 hasRelatedWork W1983832284 @default.
• W2000751577 hasRelatedWork W2017949628 @default.
• W2000751577 hasRelatedWork W2058581379 @default.
• W2000751577 hasRelatedWork W2088194175 @default.
• W2000751577 hasRelatedWork W2153336777 @default.
• W2000751577 hasRelatedWork W2225380758 @default.
• W2000751577 hasRelatedWork W2908606283 @default.
• W2000751577 hasRelatedWork W4313354898 @default.
• W2000751577 hasVolume "30" @default.

• next