Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000751609> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000751609 endingPage "268" @default.
- W2000751609 startingPage "264" @default.
- W2000751609 abstract "Many terpenes are used therapeutically, and as flavor and fragrance materials. (R)-(−)-Carvone, the main constituent of spearmint oil, and (S)-(+)-carvone, found as major component of caraway and dill seed oils, have several applications and are used in cosmetic, food, and pharmaceutical preparations. In this study, the effect of enantiomers of carvone on the central nervous system (CNS) was evaluated in mice. The LD50 value was 484.2 mg/kg (358.9–653.2) for (S)-(+)-carvone, and 426.6 (389.0–478.6) mg/kg for (R)-(−)-carvone. Both enantiomers caused depressant effects, such as decrease in the response to the touch and ambulation, increase in sedation, palpebral ptosis, and antinociceptive effects. (S)-(+)- and (R)-(−)-carvone caused a significant decrease in ambulation. (R)-(−)-Carvone appeared to be more effective than its corresponding enantiomer at 0.5 and 2.0 h after administration. However, (S)-(+)-carvone was slightly more potent at 1 h. In potentiating pentobarbital sleeping time, (R)-(−)-carvone was more effective than (S)-(+)-carvone at 100 mg/kg, but was less potent at 200 mg/kg compared to the (+)-enantiomer, indicating a sedative action. (S)-(+)-Carvone at the dose of 200 mg/kg increased significantly the latency of convulsions induced by PTZ and PIC, but (R)-(−)-carvone was not effective against these convulsions. These results suggest that (S)-(+)-carvone and (R)-(−)-carvone have depressant effect in the CNS. (S)-(+)-Carvone appears to have anticonvulsant-like activity. Chirality, 2007. © 2007 Wiley-Liss, Inc." @default.
- W2000751609 created "2016-06-24" @default.
- W2000751609 creator A5021153759 @default.
- W2000751609 creator A5052797469 @default.
- W2000751609 creator A5062849147 @default.
- W2000751609 date "2007-01-01" @default.
- W2000751609 modified "2023-10-04" @default.
- W2000751609 title "Influence of the chirality of (R)-(−)- and (S)-(+)-carvone in the central nervous system: A comparative study" @default.
- W2000751609 cites W1493215136 @default.
- W2000751609 cites W1964809668 @default.
- W2000751609 cites W1971411524 @default.
- W2000751609 cites W1974183544 @default.
- W2000751609 cites W1983417225 @default.
- W2000751609 cites W1985627332 @default.
- W2000751609 cites W1994658462 @default.
- W2000751609 cites W2028728671 @default.
- W2000751609 cites W2030405777 @default.
- W2000751609 cites W2031888636 @default.
- W2000751609 cites W2045404359 @default.
- W2000751609 cites W2045562324 @default.
- W2000751609 cites W2052381408 @default.
- W2000751609 cites W2059602076 @default.
- W2000751609 cites W2085189307 @default.
- W2000751609 cites W2099262377 @default.
- W2000751609 cites W2121639171 @default.
- W2000751609 cites W2127370631 @default.
- W2000751609 cites W2128236626 @default.
- W2000751609 cites W2164664191 @default.
- W2000751609 cites W2949998354 @default.
- W2000751609 doi "https://doi.org/10.1002/chir.20379" @default.
- W2000751609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17299731" @default.
- W2000751609 hasPublicationYear "2007" @default.
- W2000751609 type Work @default.
- W2000751609 sameAs 2000751609 @default.
- W2000751609 citedByCount "90" @default.
- W2000751609 countsByYear W20007516092012 @default.
- W2000751609 countsByYear W20007516092013 @default.
- W2000751609 countsByYear W20007516092014 @default.
- W2000751609 countsByYear W20007516092015 @default.
- W2000751609 countsByYear W20007516092016 @default.
- W2000751609 countsByYear W20007516092017 @default.
- W2000751609 countsByYear W20007516092018 @default.
- W2000751609 countsByYear W20007516092019 @default.
- W2000751609 countsByYear W20007516092020 @default.
- W2000751609 countsByYear W20007516092021 @default.
- W2000751609 countsByYear W20007516092022 @default.
- W2000751609 countsByYear W20007516092023 @default.
- W2000751609 crossrefType "journal-article" @default.
- W2000751609 hasAuthorship W2000751609A5021153759 @default.
- W2000751609 hasAuthorship W2000751609A5052797469 @default.
- W2000751609 hasAuthorship W2000751609A5062849147 @default.
- W2000751609 hasConcept C185592680 @default.
- W2000751609 hasConcept C2776134268 @default.
- W2000751609 hasConcept C2776814716 @default.
- W2000751609 hasConcept C2777278459 @default.
- W2000751609 hasConcept C2778240251 @default.
- W2000751609 hasConcept C2778279090 @default.
- W2000751609 hasConcept C31903555 @default.
- W2000751609 hasConcept C44937612 @default.
- W2000751609 hasConcept C486523 @default.
- W2000751609 hasConcept C71240020 @default.
- W2000751609 hasConcept C71924100 @default.
- W2000751609 hasConcept C98274493 @default.
- W2000751609 hasConceptScore W2000751609C185592680 @default.
- W2000751609 hasConceptScore W2000751609C2776134268 @default.
- W2000751609 hasConceptScore W2000751609C2776814716 @default.
- W2000751609 hasConceptScore W2000751609C2777278459 @default.
- W2000751609 hasConceptScore W2000751609C2778240251 @default.
- W2000751609 hasConceptScore W2000751609C2778279090 @default.
- W2000751609 hasConceptScore W2000751609C31903555 @default.
- W2000751609 hasConceptScore W2000751609C44937612 @default.
- W2000751609 hasConceptScore W2000751609C486523 @default.
- W2000751609 hasConceptScore W2000751609C71240020 @default.
- W2000751609 hasConceptScore W2000751609C71924100 @default.
- W2000751609 hasConceptScore W2000751609C98274493 @default.
- W2000751609 hasIssue "4" @default.
- W2000751609 hasLocation W20007516091 @default.
- W2000751609 hasLocation W20007516092 @default.
- W2000751609 hasOpenAccess W2000751609 @default.
- W2000751609 hasPrimaryLocation W20007516091 @default.
- W2000751609 hasRelatedWork W1977280839 @default.
- W2000751609 hasRelatedWork W2018884268 @default.
- W2000751609 hasRelatedWork W2020773582 @default.
- W2000751609 hasRelatedWork W2021432255 @default.
- W2000751609 hasRelatedWork W2047000107 @default.
- W2000751609 hasRelatedWork W2051662115 @default.
- W2000751609 hasRelatedWork W2057312648 @default.
- W2000751609 hasRelatedWork W2073238816 @default.
- W2000751609 hasRelatedWork W2381726486 @default.
- W2000751609 hasRelatedWork W3178808641 @default.
- W2000751609 hasVolume "19" @default.
- W2000751609 isParatext "false" @default.
- W2000751609 isRetracted "false" @default.
- W2000751609 magId "2000751609" @default.
- W2000751609 workType "article" @default.