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- W2000751904 abstract "A form of steroid sulphate sulphohydrolase (EC 3.1.6.2) hydrolysing the dehydroepiandrosterone sulphate (DHEAS-ase) was purified from human placenta microsomes. During the purification procedure the DHEAS-ase was separated from the oestrone sulphate sulphohydrolase (OS-ase). The purified DHEAS-ase revealed specific activity of 1520 nmolxmin-1xmgprotein-1 and exhibited optimal activity at pH 8.4. The Km value was established to be 3.3+/-0.07x10(-5) M. The pI value was around 8.7. The molecular weight estimated by gel filtration was 7.4 kDa. The purified DHEAS-ase was not sensitive to the common sulphohydrolase inhibitors, such as phosphate, sulphate and sulphide ions, but was inhibited by several phosphohydrolase inhibitors (ammonium molybdate, vanadium oxide(V), zinc acetate). Steroids effected inhibition or activation of the purified enzyme. The data concerning substances reacting with -SH groups suggest that in the physiological conditions DHEAS-ase is controlled by the redox status of the cell." @default.
- W2000751904 created "2016-06-24" @default.
- W2000751904 creator A5026132296 @default.
- W2000751904 creator A5071977109 @default.
- W2000751904 date "2006-04-01" @default.
- W2000751904 modified "2023-09-27" @default.
- W2000751904 title "Dehydroepiandrosterone sulphate sulphoydrolase from human placenta microsomes—Properties of the purified enzyme" @default.
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- W2000751904 doi "https://doi.org/10.1016/j.jsbmb.2005.11.008" @default.
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