Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000752062> ?p ?o ?g. }
- W2000752062 endingPage "2196" @default.
- W2000752062 startingPage "2180" @default.
- W2000752062 abstract "pH-responsive transcription factors of the Rim101/PacC family govern virulence in many fungal pathogens. These family members control expression of target genes with diverse functions in growth, morphology and environmental adaptation, so the mechanistic relationship between Rim101/PacC and infection is unclear. We have focused on Rim101 from Candida albicans, which we find to be required for virulence in an oropharyngeal candidiasis model. Rim101 affects the yeast-hypha morphological transition, a major virulence requirement in disseminated infection models. However, virulence in the oropharyngeal candidiasis model is independent of the yeast-hypha transition because it is unaffected by an nrg1 mutation, which prevents formation of yeast cells. Here we have identified Rim101 target genes in an nrg1Delta/Delta mutant background and surveyed function using an overexpression-rescue approach. Increased expression of Rim101 target genes ALS3, CHT2, PGA7/RBT6, SKN1 or ZRT1 can partially restore pathogenic interaction of a rim101Delta/Delta mutant with oral epithelial cells. Four of these five genes govern cell wall structure. Our results indicate that Rim101-dependent cell wall alteration contributes to C. albicans pathogenic interactions with oral epithelial cells, independently of cell morphology." @default.
- W2000752062 created "2016-06-24" @default.
- W2000752062 creator A5003443617 @default.
- W2000752062 creator A5012804086 @default.
- W2000752062 creator A5024622354 @default.
- W2000752062 creator A5033587764 @default.
- W2000752062 creator A5061898922 @default.
- W2000752062 creator A5066754592 @default.
- W2000752062 creator A5085476804 @default.
- W2000752062 creator A5088276536 @default.
- W2000752062 date "2008-11-01" @default.
- W2000752062 modified "2023-10-17" @default.
- W2000752062 title "<i>Candida albicans</i>transcription factor Rim101 mediates pathogenic interactions through cell wall functions" @default.
- W2000752062 cites W1500387969 @default.
- W2000752062 cites W1510820311 @default.
- W2000752062 cites W1521075280 @default.
- W2000752062 cites W1895329547 @default.
- W2000752062 cites W1970770879 @default.
- W2000752062 cites W1999340863 @default.
- W2000752062 cites W2002221873 @default.
- W2000752062 cites W2002995933 @default.
- W2000752062 cites W2003004599 @default.
- W2000752062 cites W2008893410 @default.
- W2000752062 cites W2011758386 @default.
- W2000752062 cites W2019352808 @default.
- W2000752062 cites W2025805745 @default.
- W2000752062 cites W2027551094 @default.
- W2000752062 cites W2032231928 @default.
- W2000752062 cites W2048093614 @default.
- W2000752062 cites W2049621303 @default.
- W2000752062 cites W2052352927 @default.
- W2000752062 cites W2059692941 @default.
- W2000752062 cites W2060322845 @default.
- W2000752062 cites W2066976786 @default.
- W2000752062 cites W2070265193 @default.
- W2000752062 cites W2072152345 @default.
- W2000752062 cites W2074233079 @default.
- W2000752062 cites W2082336865 @default.
- W2000752062 cites W2089819283 @default.
- W2000752062 cites W2090775633 @default.
- W2000752062 cites W2102230982 @default.
- W2000752062 cites W2103453943 @default.
- W2000752062 cites W2103890028 @default.
- W2000752062 cites W2104507335 @default.
- W2000752062 cites W2105190386 @default.
- W2000752062 cites W2106387328 @default.
- W2000752062 cites W2111728249 @default.
- W2000752062 cites W2111737725 @default.
- W2000752062 cites W2112310296 @default.
- W2000752062 cites W2116721311 @default.
- W2000752062 cites W2118657913 @default.
- W2000752062 cites W2119507799 @default.
- W2000752062 cites W2126597545 @default.
- W2000752062 cites W2126709095 @default.
- W2000752062 cites W2127955452 @default.
- W2000752062 cites W2129227816 @default.
- W2000752062 cites W2133183053 @default.
- W2000752062 cites W2134152581 @default.
- W2000752062 cites W2134285655 @default.
- W2000752062 cites W2134664980 @default.
- W2000752062 cites W2135491132 @default.
- W2000752062 cites W2135707527 @default.
- W2000752062 cites W2137044047 @default.
- W2000752062 cites W2140865595 @default.
- W2000752062 cites W2143629991 @default.
- W2000752062 cites W2147569756 @default.
- W2000752062 cites W2153543327 @default.
- W2000752062 cites W2155494286 @default.
- W2000752062 cites W2155890726 @default.
- W2000752062 cites W2157766752 @default.
- W2000752062 cites W2161575072 @default.
- W2000752062 cites W2164116124 @default.
- W2000752062 doi "https://doi.org/10.1111/j.1462-5822.2008.01198.x" @default.
- W2000752062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2701370" @default.
- W2000752062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18627379" @default.
- W2000752062 hasPublicationYear "2008" @default.
- W2000752062 type Work @default.
- W2000752062 sameAs 2000752062 @default.
- W2000752062 citedByCount "137" @default.
- W2000752062 countsByYear W20007520622012 @default.
- W2000752062 countsByYear W20007520622013 @default.
- W2000752062 countsByYear W20007520622014 @default.
- W2000752062 countsByYear W20007520622015 @default.
- W2000752062 countsByYear W20007520622016 @default.
- W2000752062 countsByYear W20007520622017 @default.
- W2000752062 countsByYear W20007520622018 @default.
- W2000752062 countsByYear W20007520622019 @default.
- W2000752062 countsByYear W20007520622020 @default.
- W2000752062 countsByYear W20007520622021 @default.
- W2000752062 countsByYear W20007520622022 @default.
- W2000752062 countsByYear W20007520622023 @default.
- W2000752062 crossrefType "journal-article" @default.
- W2000752062 hasAuthorship W2000752062A5003443617 @default.
- W2000752062 hasAuthorship W2000752062A5012804086 @default.
- W2000752062 hasAuthorship W2000752062A5024622354 @default.
- W2000752062 hasAuthorship W2000752062A5033587764 @default.
- W2000752062 hasAuthorship W2000752062A5061898922 @default.
- W2000752062 hasAuthorship W2000752062A5066754592 @default.