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• W2000753264 endingPage "480" @default.
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• W2000753264 abstract "Summary Type I interferons (IFNs) are widely used therapeutically. IFN-α2a in particular is used as an antiviral agent, but its immunomodulatory properties are poorly understood. Dendritic cells (DCs) are the only antigen-presenting cells able to prime naive T cells and therefore play a crucial role in initiating the adaptive phase of the immune response. We studied the effects of IFN-α2a on DC maturation and its role in determining Th1/Th2 equilibrium. We found that IFN-α2a induced phenotypic maturation of DCs and increased their allostimulatory capacity. When dendritic cells were stimulated simultaneously by CD40 ligation and IFN-α2a, the production of interleukin (IL)-10 and IL-12 was increased. In contrast, lipopolysaccharide (LPS) stimulation in the presence of IFN-α2a mainly induced IL-10 release. The production of IFN-γ and IL-5 by the responder naive T cells was also amplified in response to IFN-α2a-treated DCs. Furthermore, IL-12 production by IFN-α2a-treated DCs was enhanced further in the presence of anti-IL-10 antibody. Different results were obtained when DCs were treated simultaneously with IFN-α2a and other maturation factors, in particular LPS, and then stimulated by CD40 ligation 36 h later. Under these circumstances, IFN-α2a did not modify the DC phenotype, and the production of IL-10/IL-12 and IFN-γ/IL-5 by DCs and by DC-stimulated naive T cells, respectively, was inhibited compared to the effects on DCs treated with maturation factors alone. Altogether, this work suggests that IFN-α2a in isolation is sufficient to promote DC activation, however, other concomitant events, such as exposure to LPS during a bacterial infection, can inhibit its effects. These results clarify some of the in vivo findings obtained with IFN-α2a and have direct implications for the design of IFN-α-based vaccines for immunotherapy." @default.
• W2000753264 created "2016-06-24" @default.
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• W2000753264 date "2005-09-11" @default.
• W2000753264 modified "2023-09-26" @default.
• W2000753264 title "Interferon-α2a is sufficient for promoting dendritic cell immunogenicity" @default.
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• W2000753264 doi "https://doi.org/10.1111/j.1365-2249.2005.02933.x" @default.
• W2000753264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809533" @default.
• W2000753264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16297159" @default.
• W2000753264 hasPublicationYear "2005" @default.
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