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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000754408> ?p ?o ?g. }

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• W2000754408 abstract "BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHbeta subunit gene transcription in the murine gonadotroph cell line, LbetaT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid." @default.
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• W2000754408 date "2010-09-15" @default.
• W2000754408 modified "2023-10-09" @default.
• W2000754408 title "Pituitary tumors: Cell type-specific roles for BMP-4" @default.
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• W2000754408 doi "https://doi.org/10.1016/j.mce.2010.04.006" @default.
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