FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000755458> ?p ?o ?g. }

• W2000755458 endingPage "405" @default.
• W2000755458 startingPage "399" @default.
• W2000755458 abstract "Calcitriol, the principal biologically active ligand of the Vitamin D receptor (VDR), has been shown to inhibit cancer cell proliferation in in vitro and in vivo models of prostate cancer and a wide range of other neoplasms. In addition, calcitriol’s activity appears to be additive, and in some experimental systems, synergistic with dexamethasone and several cytotoxic chemotherapy agents. While effects on progression through the cell cycle, induction of apoptosis, inhibition of angiogenesis, and reduction in tumor invasiveness have been demonstrated, the exact mechanisms of VDR-mediated antineoplastic activity remain incompletely understood. Antineoplastic activity of calcitriol requires substantially supraphysiologic concentrations of this compound. Dose escalation of calcitriol administered daily was severely limited by predictable hypercalcemia and/or hypercalcuria. This limitation has been overcome with intermittent dosing of calcitriol. At Oregon Health & Science University, weekly oral administration of calcitriol allowed the attainment of peak serum calcitriol concentrations well above 1 nM, a concentration that inhibits prostate cancer proliferation by more than 50% in vitro. Weekly high-dose calcitriol was then combined with weekly docetaxel in a Phase II clinical trial carried out in men with metastatic androgen-independent prostate cancer. Treatment resulted in PSA response (defined as a confirmed 50% reduction) in 81% of patients. This level of activity, as well as the median time to progression of 11.4 months and median survival of 19.5 months, compared favorably to results with docetaxel alone and led to the development of a recently initiated randomized trial of docetaxel with calcitriol or placebo in the same patient population." @default.
• W2000755458 created "2016-06-24" @default.
• W2000755458 creator A5048477205 @default.
• W2000755458 date "2003-09-01" @default.
• W2000755458 modified "2023-10-01" @default.
• W2000755458 title "Development of weekly high-dose calcitriol based therapy for prostate cancer" @default.
• W2000755458 cites W1485317916 @default.
• W2000755458 cites W1932317695 @default.
• W2000755458 cites W1966978530 @default.
• W2000755458 cites W1969219345 @default.
• W2000755458 cites W1971159467 @default.
• W2000755458 cites W1980123375 @default.
• W2000755458 cites W1986657087 @default.
• W2000755458 cites W1993612650 @default.
• W2000755458 cites W1996203783 @default.
• W2000755458 cites W2003575314 @default.
• W2000755458 cites W2006368250 @default.
• W2000755458 cites W2008715326 @default.
• W2000755458 cites W2013850508 @default.
• W2000755458 cites W2015078959 @default.
• W2000755458 cites W2017442652 @default.
• W2000755458 cites W2020006661 @default.
• W2000755458 cites W2030965046 @default.
• W2000755458 cites W2033386867 @default.
• W2000755458 cites W2033538744 @default.
• W2000755458 cites W2036088433 @default.
• W2000755458 cites W2036957227 @default.
• W2000755458 cites W2041325197 @default.
• W2000755458 cites W2047461289 @default.
• W2000755458 cites W2051176263 @default.
• W2000755458 cites W2053443870 @default.
• W2000755458 cites W2053571455 @default.
• W2000755458 cites W2054383376 @default.
• W2000755458 cites W2064536538 @default.
• W2000755458 cites W2070509236 @default.
• W2000755458 cites W2079692670 @default.
• W2000755458 cites W2082618019 @default.
• W2000755458 cites W2114578836 @default.
• W2000755458 cites W2121758849 @default.
• W2000755458 cites W2137427380 @default.
• W2000755458 cites W2153086817 @default.
• W2000755458 cites W2155430176 @default.
• W2000755458 cites W2162741492 @default.
• W2000755458 cites W2167132436 @default.
• W2000755458 cites W2172256092 @default.
• W2000755458 cites W2346703663 @default.
• W2000755458 cites W4241194413 @default.
• W2000755458 cites W4244955483 @default.
• W2000755458 cites W4254967846 @default.
• W2000755458 cites W4298312879 @default.
• W2000755458 cites W4323874020 @default.
• W2000755458 doi "https://doi.org/10.1016/s1078-1439(03)00170-4" @default.
• W2000755458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14670552" @default.
• W2000755458 hasPublicationYear "2003" @default.
• W2000755458 type Work @default.
• W2000755458 sameAs 2000755458 @default.
• W2000755458 citedByCount "35" @default.
• W2000755458 countsByYear W20007554582012 @default.
• W2000755458 countsByYear W20007554582013 @default.
• W2000755458 countsByYear W20007554582014 @default.
• W2000755458 countsByYear W20007554582015 @default.
• W2000755458 countsByYear W20007554582016 @default.
• W2000755458 countsByYear W20007554582017 @default.
• W2000755458 countsByYear W20007554582021 @default.
• W2000755458 countsByYear W20007554582022 @default.
• W2000755458 crossrefType "journal-article" @default.
• W2000755458 hasAuthorship W2000755458A5048477205 @default.
• W2000755458 hasConcept C121608353 @default.
• W2000755458 hasConcept C124490489 @default.
• W2000755458 hasConcept C126322002 @default.
• W2000755458 hasConcept C134018914 @default.
• W2000755458 hasConcept C143998085 @default.
• W2000755458 hasConcept C179639408 @default.
• W2000755458 hasConcept C2776079296 @default.
• W2000755458 hasConcept C2780192828 @default.
• W2000755458 hasConcept C2781190966 @default.
• W2000755458 hasConcept C2908647359 @default.
• W2000755458 hasConcept C502942594 @default.
• W2000755458 hasConcept C71924100 @default.
• W2000755458 hasConcept C98274493 @default.
• W2000755458 hasConcept C99454951 @default.
• W2000755458 hasConceptScore W2000755458C121608353 @default.
• W2000755458 hasConceptScore W2000755458C124490489 @default.
• W2000755458 hasConceptScore W2000755458C126322002 @default.
• W2000755458 hasConceptScore W2000755458C134018914 @default.
• W2000755458 hasConceptScore W2000755458C143998085 @default.
• W2000755458 hasConceptScore W2000755458C179639408 @default.
• W2000755458 hasConceptScore W2000755458C2776079296 @default.
• W2000755458 hasConceptScore W2000755458C2780192828 @default.
• W2000755458 hasConceptScore W2000755458C2781190966 @default.
• W2000755458 hasConceptScore W2000755458C2908647359 @default.
• W2000755458 hasConceptScore W2000755458C502942594 @default.
• W2000755458 hasConceptScore W2000755458C71924100 @default.
• W2000755458 hasConceptScore W2000755458C98274493 @default.
• W2000755458 hasConceptScore W2000755458C99454951 @default.
• W2000755458 hasIssue "5" @default.
• W2000755458 hasLocation W20007554581 @default.
• W2000755458 hasLocation W20007554582 @default.

• next