FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000755812> ?p ?o ?g. }

• W2000755812 endingPage "51" @default.
• W2000755812 startingPage "36" @default.
• W2000755812 abstract "The limited value of in vitro toxicity data for the in vivo extrapolation has been often attributed to the lack of kinetic data. Here the in vitro kinetics of amiodarone (AMI) and its mono-N-desethyl (MDEA) metabolite was determined and modelled in primary human hepatocytes (PHH) and HepaRG cells, after single and repeated administration of clinically relevant concentrations. AMI bioavailability was influenced by adsorption to the plastic and the presence of protein in the medium (e.g. 10% serum protein reduced the uptake by half in HepaRG cells). The cell uptake was quick (within 3 h), AMI metabolism was efficient and a dynamic equilibrium was reached in about a week after multiple dosing. In HepaRG cells the metabolic clearance was higher than in PHH and increased over time, as well as CYP3A4. The interindividual variability in MDEA production in PHHs was not proportional to the differences in CYP3A4 activities, suggesting the involvement of other CYPs and/or AMI-related CYP inhibition. After repeated treatment AMI showed a slight potential for bioaccumulation, whereas much higher intracellular MDEA levels accumulated over time, especially in the HepaRG cells, associated with occurrence of phospholipidosis. The knowledge of in vitro biokinetics is important to transform an actual in vitro concentration–effect into an in vivo dose–effect relationship by using appropriate modelling, thus improving the in vitro-to-in vivo extrapolation." @default.
• W2000755812 created "2016-06-24" @default.
• W2000755812 creator A5000680884 @default.
• W2000755812 creator A5012795625 @default.
• W2000755812 creator A5021796710 @default.
• W2000755812 creator A5025048918 @default.
• W2000755812 creator A5036803515 @default.
• W2000755812 creator A5049113548 @default.
• W2000755812 creator A5058587451 @default.
• W2000755812 creator A5073991336 @default.
• W2000755812 creator A5088509681 @default.
• W2000755812 date "2015-12-01" @default.
• W2000755812 modified "2023-10-16" @default.
• W2000755812 title "In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments" @default.
• W2000755812 cites W1519703013 @default.
• W2000755812 cites W1603529942 @default.
• W2000755812 cites W1703321169 @default.
• W2000755812 cites W1822042631 @default.
• W2000755812 cites W1967637682 @default.
• W2000755812 cites W1968728653 @default.
• W2000755812 cites W1969237577 @default.
• W2000755812 cites W1971763588 @default.
• W2000755812 cites W1980455299 @default.
• W2000755812 cites W1988057529 @default.
• W2000755812 cites W1994462665 @default.
• W2000755812 cites W2002449738 @default.
• W2000755812 cites W2019198883 @default.
• W2000755812 cites W2023813192 @default.
• W2000755812 cites W2025368702 @default.
• W2000755812 cites W2027254129 @default.
• W2000755812 cites W2051266624 @default.
• W2000755812 cites W2052026707 @default.
• W2000755812 cites W2055526313 @default.
• W2000755812 cites W2059390515 @default.
• W2000755812 cites W2066609845 @default.
• W2000755812 cites W2075611809 @default.
• W2000755812 cites W2076259394 @default.
• W2000755812 cites W2085702122 @default.
• W2000755812 cites W2086243928 @default.
• W2000755812 cites W2088749613 @default.
• W2000755812 cites W2094392052 @default.
• W2000755812 cites W2103974459 @default.
• W2000755812 cites W2106480379 @default.
• W2000755812 cites W2125160586 @default.
• W2000755812 cites W2127924963 @default.
• W2000755812 cites W2134320928 @default.
• W2000755812 cites W2137132053 @default.
• W2000755812 cites W2141887125 @default.
• W2000755812 cites W2143511244 @default.
• W2000755812 cites W2148534890 @default.
• W2000755812 cites W2149465437 @default.
• W2000755812 cites W2155812848 @default.
• W2000755812 cites W2162097198 @default.
• W2000755812 cites W2163389789 @default.
• W2000755812 cites W2165824122 @default.
• W2000755812 cites W2171534546 @default.
• W2000755812 cites W31953013 @default.
• W2000755812 cites W39086550 @default.
• W2000755812 doi "https://doi.org/10.1016/j.tiv.2014.12.012" @default.
• W2000755812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25546373" @default.
• W2000755812 hasPublicationYear "2015" @default.
• W2000755812 type Work @default.
• W2000755812 sameAs 2000755812 @default.
• W2000755812 citedByCount "32" @default.
• W2000755812 countsByYear W20007558122015 @default.
• W2000755812 countsByYear W20007558122016 @default.
• W2000755812 countsByYear W20007558122017 @default.
• W2000755812 countsByYear W20007558122018 @default.
• W2000755812 countsByYear W20007558122019 @default.
• W2000755812 countsByYear W20007558122020 @default.
• W2000755812 countsByYear W20007558122021 @default.
• W2000755812 countsByYear W20007558122022 @default.
• W2000755812 countsByYear W20007558122023 @default.
• W2000755812 crossrefType "journal-article" @default.
• W2000755812 hasAuthorship W2000755812A5000680884 @default.
• W2000755812 hasAuthorship W2000755812A5012795625 @default.
• W2000755812 hasAuthorship W2000755812A5021796710 @default.
• W2000755812 hasAuthorship W2000755812A5025048918 @default.
• W2000755812 hasAuthorship W2000755812A5036803515 @default.
• W2000755812 hasAuthorship W2000755812A5049113548 @default.
• W2000755812 hasAuthorship W2000755812A5058587451 @default.
• W2000755812 hasAuthorship W2000755812A5073991336 @default.
• W2000755812 hasAuthorship W2000755812A5088509681 @default.
• W2000755812 hasConcept C109650736 @default.
• W2000755812 hasConcept C112705442 @default.
• W2000755812 hasConcept C121332964 @default.
• W2000755812 hasConcept C148898269 @default.
• W2000755812 hasConcept C150903083 @default.
• W2000755812 hasConcept C178790620 @default.
• W2000755812 hasConcept C181389837 @default.
• W2000755812 hasConcept C185592680 @default.
• W2000755812 hasConcept C195289149 @default.
• W2000755812 hasConcept C202751555 @default.
• W2000755812 hasConcept C207001950 @default.
• W2000755812 hasConcept C2777477808 @default.
• W2000755812 hasConcept C2778918659 @default.
• W2000755812 hasConcept C2779934242 @default.
• W2000755812 hasConcept C29730261 @default.

• next