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- W2000756009 abstract "A new trifluorinated amino-combretastatin analogue, (Z)-2-(4'-methoxy-3'-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC(50)=2.9 microM), and cytotoxic against selected human cancer cell lines. This new lead compound is among the most active from a group of related structural modifications." @default.
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- W2000756009 date "2008-09-01" @default.
- W2000756009 modified "2023-09-26" @default.
- W2000756009 title "Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4" @default.
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- W2000756009 doi "https://doi.org/10.1016/j.bmcl.2008.07.070" @default.
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