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- W2000756291 abstract "The integration patterns of human papillomavirus (HPV) type 16 in the cellular DNA of six cervical carcinoma samples were analyzed by the Southern blot procedure. None of the HPV integrants retained the entire viral genome. Double HPV integration was found in one case while all other cases were single integrants. In some samples, internal deletion and selective amplification of the viral sequences were observed. On integration, the E2 open reading frame (ORF) was invariably lost but the E6/E7 ORFs and the long control region of the HPV-16 genome were retained in all seven integrations analyzed and may play a role in cellular transformation and/or maintainence of the transformed phenotype." @default.
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- W2000756291 date "1987-11-01" @default.
- W2000756291 modified "2023-10-17" @default.
- W2000756291 title "Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: Preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames" @default.
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- W2000756291 doi "https://doi.org/10.1016/0042-6822(87)90195-4" @default.
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