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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000756557> ?p ?o ?g. }

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• W2000756557 abstract "Retinoids that activate the nuclear retinoid X receptors (RXRs) display potential for chemoprevention of breast cancer. We previously reported that 9cUAB30 (1) is an RXR-selective retinoid. To explore its in vivo chemopreventive activity, multigram quantities of 1 were needed. Here, we describe a modified synthesis that yields up to 100 g of 1. We further demonstrate that 1 is very effective in the prevention of N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity." @default.
• W2000756557 created "2016-06-24" @default.
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• W2000756557 date "2003-07-23" @default.
• W2000756557 modified "2023-10-17" @default.
• W2000756557 title "Conformationally Defined Retinoic Acid Analogues. 5. Large-Scale Synthesis and Mammary Cancer Chemopreventive Activity for (2<i>E</i>,4<i>E</i>,6<i>Z</i>,8<i>E</i>)-8- (3‘,4‘-Dihydro-1‘(2‘<i>H</i>)-naphthalen-1‘-ylidene)-3,7-dimethyl-2,4,6-octatrienoic Acid (9cUAB30)" @default.
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• W2000756557 doi "https://doi.org/10.1021/jm030095q" @default.
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