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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000756633> ?p ?o ?g. }

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• W2000756633 abstract "A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization." @default.
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• W2000756633 date "1991-04-19" @default.
• W2000756633 modified "2023-09-23" @default.
• W2000756633 title "Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation" @default.
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• W2000756633 doi "https://doi.org/10.1126/science.1826797" @default.
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