Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000757194> ?p ?o ?g. }
- W2000757194 abstract "Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance. This inhibition of reproductive function during negative energy balance occurs due to suppression of gonadotropin-releasing hormone (GnRH) release in the hypothalamus. The GnRH secretagogue kisspeptin is also inhibited during negative energy balance, indicating that inhibition of reproductive neuroendocrine circuits may occur upstream of GnRH itself. Understanding the metabolic signals responsible for the inhibition of reproductive pathways has been a compelling research focus for many years. A predominant theory in the field is that the status of energy balance is conveyed to reproductive neuroendocrine circuits via the adipocyte hormone leptin. Leptin is stimulatory for GnRH release and lower levels of leptin during negative energy balance are believed to result in decreased stimulatory drive for GnRH cells. However, recent evidence found that restoring leptin to physiological levels did not restore GnRH function in three different models of negative energy balance. This suggests that although leptin may be an important permissive signal for reproductive function as indicated by many years of research, factors other than leptin must critically contribute to negative energy balance-induced reproductive inhibition. This review will focus on emerging candidates for the integration of metabolic status and reproductive function during negative energy balance." @default.
- W2000757194 created "2016-06-24" @default.
- W2000757194 creator A5026104880 @default.
- W2000757194 creator A5027981285 @default.
- W2000757194 creator A5047336215 @default.
- W2000757194 date "2011-01-01" @default.
- W2000757194 modified "2023-09-30" @default.
- W2000757194 title "Beyond Leptin: Emerging Candidates for the Integration of Metabolic and Reproductive Function during Negative Energy Balance" @default.
- W2000757194 cites W1489541636 @default.
- W2000757194 cites W1511601172 @default.
- W2000757194 cites W1540547666 @default.
- W2000757194 cites W1545663099 @default.
- W2000757194 cites W1549225872 @default.
- W2000757194 cites W1574613661 @default.
- W2000757194 cites W1596559390 @default.
- W2000757194 cites W1637971961 @default.
- W2000757194 cites W1639930240 @default.
- W2000757194 cites W1693928862 @default.
- W2000757194 cites W1847835171 @default.
- W2000757194 cites W1880891411 @default.
- W2000757194 cites W1895210219 @default.
- W2000757194 cites W1960258372 @default.
- W2000757194 cites W1965208925 @default.
- W2000757194 cites W1969453048 @default.
- W2000757194 cites W1972602091 @default.
- W2000757194 cites W1972630529 @default.
- W2000757194 cites W1973721115 @default.
- W2000757194 cites W1974118452 @default.
- W2000757194 cites W1974677042 @default.
- W2000757194 cites W1975890243 @default.
- W2000757194 cites W1977250427 @default.
- W2000757194 cites W1977865535 @default.
- W2000757194 cites W1977946309 @default.
- W2000757194 cites W1979000159 @default.
- W2000757194 cites W1979588495 @default.
- W2000757194 cites W1981585384 @default.
- W2000757194 cites W1981762970 @default.
- W2000757194 cites W1984028801 @default.
- W2000757194 cites W1989680524 @default.
- W2000757194 cites W1989917638 @default.
- W2000757194 cites W1991106959 @default.
- W2000757194 cites W1993413620 @default.
- W2000757194 cites W1994991637 @default.
- W2000757194 cites W1995422872 @default.
- W2000757194 cites W1995447275 @default.
- W2000757194 cites W1995784069 @default.
- W2000757194 cites W1995813398 @default.
- W2000757194 cites W1995833639 @default.
- W2000757194 cites W1996825880 @default.
- W2000757194 cites W1997182615 @default.
- W2000757194 cites W1998286971 @default.
- W2000757194 cites W1999963518 @default.
- W2000757194 cites W2001542573 @default.
- W2000757194 cites W2001807748 @default.
- W2000757194 cites W2002987049 @default.
- W2000757194 cites W2004119056 @default.
- W2000757194 cites W2004525137 @default.
- W2000757194 cites W2008787696 @default.
- W2000757194 cites W2009812598 @default.
- W2000757194 cites W2010282031 @default.
- W2000757194 cites W2010521618 @default.
- W2000757194 cites W2010920434 @default.
- W2000757194 cites W2010939792 @default.
- W2000757194 cites W2011039259 @default.
- W2000757194 cites W2011431600 @default.
- W2000757194 cites W2011709649 @default.
- W2000757194 cites W2012382894 @default.
- W2000757194 cites W2013780942 @default.
- W2000757194 cites W2015741254 @default.
- W2000757194 cites W2017208259 @default.
- W2000757194 cites W2019097241 @default.
- W2000757194 cites W2022857682 @default.
- W2000757194 cites W2024749335 @default.
- W2000757194 cites W2024824446 @default.
- W2000757194 cites W2024942055 @default.
- W2000757194 cites W2027196085 @default.
- W2000757194 cites W2027437492 @default.
- W2000757194 cites W2030183538 @default.
- W2000757194 cites W2030585597 @default.
- W2000757194 cites W2030898455 @default.
- W2000757194 cites W2031463222 @default.
- W2000757194 cites W2032865136 @default.
- W2000757194 cites W2033764884 @default.
- W2000757194 cites W2035780360 @default.
- W2000757194 cites W2038039689 @default.
- W2000757194 cites W2039830249 @default.
- W2000757194 cites W2039891842 @default.
- W2000757194 cites W2040220751 @default.
- W2000757194 cites W2040817219 @default.
- W2000757194 cites W2041165166 @default.
- W2000757194 cites W2041995051 @default.
- W2000757194 cites W2044945548 @default.
- W2000757194 cites W2045050210 @default.
- W2000757194 cites W2045496850 @default.
- W2000757194 cites W2045555035 @default.
- W2000757194 cites W2045882768 @default.
- W2000757194 cites W2046628195 @default.
- W2000757194 cites W2051081976 @default.
- W2000757194 cites W2053268739 @default.
- W2000757194 cites W2053426841 @default.