FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000757300> ?p ?o ?g. }

• W2000757300 abstract "Tiapamil (Ro 11-1781) is a new calcium antagonist. Several investigators have reported about its efficacy against cardiac arrhythmias and angina pectoris. However, there was no study that assessed a possible relationship between hemodynamic effects and plasma concentration. Our study was aimed to investigate any possible relationship between cardiovascular effects of tiapamil and its plasma concentration. We selected 8 coronary; patients (6 males and 2 females) with a mean age of 61.9 yr and a mean weight of 70.9 kg. Tiapamil was administered per os at the dose of 250 mg t.i.d. for 4 consecutive days. Hemodynamic data were obtained by means of echocardiography, ECG and sphygmomanometry. Plasma concentrations of Ro 11-1781 and its major metabolites were measured by means of high pressure liquid chromatography. With tiapamil, the morning systolic BP fell from 130.6 +/- 19.5 (mean +/- SD, pretreatment) to 114.4 +/- 18.2 mm Hg on day 4, the change being clinically and statistically significant (P less than 0.02 by paired t-tests). Diastolic BP and HR remained unchanged. LVEDD and LVESD were not affected to any relevant extent, but VCF was significantly (P less than 0.05) and persistently increased. Tiapamil was well absorbed, but large interindividual variations were observed. As a general rule, no direct relationship between plasma concentrations and hemodynamic effects could be demonstrated. However, the number of patients is too small to allow general conclusions. At the above dose, tiapamil did not elicit any clinically detectable negative inotropic or negative chronotropic effect, probably because of its lowering effect on systolic BP." @default.
• W2000757300 created "2016-06-24" @default.
• W2000757300 creator A5011491793 @default.
• W2000757300 creator A5034907567 @default.
• W2000757300 creator A5054603809 @default.
• W2000757300 creator A5068682032 @default.
• W2000757300 creator A5075004709 @default.
• W2000757300 date "1981-01-01" @default.
• W2000757300 modified "2023-09-27" @default.
• W2000757300 title "Serial M-mode echocardiography in evaluation of the cardiovascular effects of tiapamil and their relationship to plasma levels in patients with coronary heart disease" @default.
• W2000757300 cites W1483396631 @default.
• W2000757300 cites W1974443948 @default.
• W2000757300 cites W2001396507 @default.
• W2000757300 cites W2007094267 @default.
• W2000757300 cites W2031481647 @default.
• W2000757300 cites W2033292054 @default.
• W2000757300 cites W2048984793 @default.
• W2000757300 cites W2076184039 @default.
• W2000757300 cites W2077880614 @default.
• W2000757300 cites W2126719023 @default.
• W2000757300 cites W2156880631 @default.
• W2000757300 cites W2409779748 @default.
• W2000757300 cites W2418947227 @default.
• W2000757300 cites W2426962558 @default.
• W2000757300 cites W2952242066 @default.
• W2000757300 doi "https://doi.org/10.1016/0167-5273(81)90042-5" @default.
• W2000757300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7333712" @default.
• W2000757300 hasPublicationYear "1981" @default.
• W2000757300 type Work @default.
• W2000757300 sameAs 2000757300 @default.
• W2000757300 citedByCount "4" @default.
• W2000757300 crossrefType "journal-article" @default.
• W2000757300 hasAuthorship W2000757300A5011491793 @default.
• W2000757300 hasAuthorship W2000757300A5034907567 @default.
• W2000757300 hasAuthorship W2000757300A5054603809 @default.
• W2000757300 hasAuthorship W2000757300A5068682032 @default.
• W2000757300 hasAuthorship W2000757300A5075004709 @default.
• W2000757300 hasConcept C126322002 @default.
• W2000757300 hasConcept C155710745 @default.
• W2000757300 hasConcept C158328960 @default.
• W2000757300 hasConcept C164705383 @default.
• W2000757300 hasConcept C178853913 @default.
• W2000757300 hasConcept C19720800 @default.
• W2000757300 hasConcept C2777953023 @default.
• W2000757300 hasConcept C57900726 @default.
• W2000757300 hasConcept C71924100 @default.
• W2000757300 hasConcept C84393581 @default.
• W2000757300 hasConceptScore W2000757300C126322002 @default.
• W2000757300 hasConceptScore W2000757300C155710745 @default.
• W2000757300 hasConceptScore W2000757300C158328960 @default.
• W2000757300 hasConceptScore W2000757300C164705383 @default.
• W2000757300 hasConceptScore W2000757300C178853913 @default.
• W2000757300 hasConceptScore W2000757300C19720800 @default.
• W2000757300 hasConceptScore W2000757300C2777953023 @default.
• W2000757300 hasConceptScore W2000757300C57900726 @default.
• W2000757300 hasConceptScore W2000757300C71924100 @default.
• W2000757300 hasConceptScore W2000757300C84393581 @default.
• W2000757300 hasLocation W20007573001 @default.
• W2000757300 hasLocation W20007573002 @default.
• W2000757300 hasOpenAccess W2000757300 @default.
• W2000757300 hasPrimaryLocation W20007573001 @default.
• W2000757300 hasRelatedWork W2018582364 @default.
• W2000757300 hasRelatedWork W2029383502 @default.
• W2000757300 hasRelatedWork W2042098878 @default.
• W2000757300 hasRelatedWork W2071712163 @default.
• W2000757300 hasRelatedWork W2131884110 @default.
• W2000757300 hasRelatedWork W2352905940 @default.
• W2000757300 hasRelatedWork W2405821433 @default.
• W2000757300 hasRelatedWork W2414271538 @default.
• W2000757300 hasRelatedWork W2425294864 @default.
• W2000757300 hasRelatedWork W2435959503 @default.
• W2000757300 isParatext "false" @default.
• W2000757300 isRetracted "false" @default.
• W2000757300 magId "2000757300" @default.
• W2000757300 workType "article" @default.