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• W2000757891 abstract "Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tPA expression and BDNF maturation in relation with modifications of their cognitive performances. Our data indicate that maintenance in enriched housing led to a reversal of age-associated decrease in expression of hippocampal tPA. A subsequent increase in the level of mature BDNF and an improvement in emotional and spatial memories were observed. Taken together, these data suggest that the tPA–BDNF axis could play a critical role in the control of cognitive functions influenced both by the age and housing conditions." @default.
• W2000757891 created "2016-06-24" @default.
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• W2000757891 date "2011-09-01" @default.
• W2000757891 modified "2023-09-25" @default.
• W2000757891 title "Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF" @default.
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• W2000757891 doi "https://doi.org/10.1016/j.nlm.2011.03.004" @default.
• W2000757891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21440650" @default.
• W2000757891 hasPublicationYear "2011" @default.
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