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- W2000757997 abstract "The federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains. Here, we review what is currently known about the effects that pharmacological or genetic mammalian target of rapamycin (mTOR) inhibition have on mammalian aging and longevity. Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments." @default.
- W2000757997 created "2016-06-24" @default.
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- W2000757997 date "2014-07-12" @default.
- W2000757997 modified "2023-10-15" @default.
- W2000757997 title "Longevity, aging and rapamycin" @default.
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- W2000757997 cites W1969905238 @default.
- W2000757997 cites W1970637701 @default.
- W2000757997 cites W1973856122 @default.
- W2000757997 cites W1976065134 @default.
- W2000757997 cites W1980048146 @default.
- W2000757997 cites W1981229013 @default.
- W2000757997 cites W1983698019 @default.
- W2000757997 cites W1994305081 @default.
- W2000757997 cites W1995048468 @default.
- W2000757997 cites W1995466259 @default.
- W2000757997 cites W2001568034 @default.
- W2000757997 cites W2002741326 @default.
- W2000757997 cites W2008200942 @default.
- W2000757997 cites W2008414953 @default.
- W2000757997 cites W2008825756 @default.
- W2000757997 cites W2008932991 @default.
- W2000757997 cites W2009602165 @default.
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- W2000757997 cites W2025133084 @default.
- W2000757997 cites W2035965301 @default.
- W2000757997 cites W2036781838 @default.
- W2000757997 cites W2039196160 @default.
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- W2000757997 cites W2045201133 @default.
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- W2000757997 cites W2157739976 @default.
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- W2000757997 doi "https://doi.org/10.1007/s00018-014-1677-1" @default.
- W2000757997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4207939" @default.
- W2000757997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25015322" @default.
- W2000757997 hasPublicationYear "2014" @default.
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