FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000758020> ?p ?o ?g. }

• W2000758020 endingPage "257" @default.
• W2000758020 startingPage "251" @default.
• W2000758020 abstract "Summary The interaction of Fc receptors for IgG (FcγRs) on monocytes/macrophages with immune complexes (IC) triggers regulatory and effector functions. Previous studies have shown that FcγR–IC interactions inhibit the IFN-γ-induced expression of MHC class II in murine macrophages. However, the mechanism(s) responsible for these effects have not been elucidated. In addition, whether this IC-dependent effect also occurs in human cells is not known. Taking into account the fact that IC and IFN-γ are frequently found in infections and autoimmune disorders, together with the crucial role MHC class II molecules play in the regulation of immune response, we explored the effect and mechanism of IC-induced MHC class II down-regulation in human peripheral blood mononuclear cells (PBMC). This effect was studied either in the presence or absence of IFN-γ. We demonstrate that IC exert a drastic inhibition of basal and IFN-γ-induced expression of MHC class II on human monocytes. This effect was mediated through the interaction of IC with both FcγRI and FcγRII. Moreover, similar results were obtained using supernatants from IC-treated PBMC. The IC-induced down-regulation of MHC class II is abrogated by pepstatin and phosphoramidon, supporting the role of aspartic protease(s) and metalloprotease(s) in this process. In parallel with MHC class II expression, antigen presentation was markedly inhibited in the presence of IC." @default.
• W2000758020 created "2016-06-24" @default.
• W2000758020 creator A5022419643 @default.
• W2000758020 creator A5047196610 @default.
• W2000758020 creator A5054096863 @default.
• W2000758020 creator A5057845652 @default.
• W2000758020 creator A5065910864 @default.
• W2000758020 creator A5073954474 @default.
• W2000758020 creator A5081767592 @default.
• W2000758020 date "2001-08-01" @default.
• W2000758020 modified "2023-10-16" @default.
• W2000758020 title "Immune complexes (IC) down-regulate the basal and interferon-<i>γ</i>-induced expression of MHC Class II on human monocytes" @default.
• W2000758020 cites W115085921 @default.
• W2000758020 cites W1481714339 @default.
• W2000758020 cites W1504935934 @default.
• W2000758020 cites W1527979252 @default.
• W2000758020 cites W1572465651 @default.
• W2000758020 cites W1780375984 @default.
• W2000758020 cites W1891746319 @default.
• W2000758020 cites W1905141343 @default.
• W2000758020 cites W1907177171 @default.
• W2000758020 cites W1926962189 @default.
• W2000758020 cites W1970927662 @default.
• W2000758020 cites W1976773412 @default.
• W2000758020 cites W1978139249 @default.
• W2000758020 cites W1994805857 @default.
• W2000758020 cites W1995623595 @default.
• W2000758020 cites W2016102616 @default.
• W2000758020 cites W2044732378 @default.
• W2000758020 cites W2047206582 @default.
• W2000758020 cites W2059390370 @default.
• W2000758020 cites W2068731061 @default.
• W2000758020 cites W2098562318 @default.
• W2000758020 cites W2105360761 @default.
• W2000758020 cites W2107674548 @default.
• W2000758020 cites W2124627840 @default.
• W2000758020 cites W2150521669 @default.
• W2000758020 cites W2154901790 @default.
• W2000758020 cites W2159334023 @default.
• W2000758020 cites W2169884373 @default.
• W2000758020 cites W2182180814 @default.
• W2000758020 cites W2398896441 @default.
• W2000758020 cites W2399843602 @default.
• W2000758020 cites W2417106587 @default.
• W2000758020 cites W4249736906 @default.
• W2000758020 cites W4313333777 @default.
• W2000758020 cites W87082738 @default.
• W2000758020 doi "https://doi.org/10.1046/j.1365-2249.2001.01609.x" @default.
• W2000758020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1906131" @default.
• W2000758020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11529917" @default.
• W2000758020 hasPublicationYear "2001" @default.
• W2000758020 type Work @default.
• W2000758020 sameAs 2000758020 @default.
• W2000758020 citedByCount "11" @default.
• W2000758020 countsByYear W20007580202013 @default.
• W2000758020 crossrefType "journal-article" @default.
• W2000758020 hasAuthorship W2000758020A5022419643 @default.
• W2000758020 hasAuthorship W2000758020A5047196610 @default.
• W2000758020 hasAuthorship W2000758020A5054096863 @default.
• W2000758020 hasAuthorship W2000758020A5057845652 @default.
• W2000758020 hasAuthorship W2000758020A5065910864 @default.
• W2000758020 hasAuthorship W2000758020A5073954474 @default.
• W2000758020 hasAuthorship W2000758020A5081767592 @default.
• W2000758020 hasBestOaLocation W20007580202 @default.
• W2000758020 hasConcept C119997001 @default.
• W2000758020 hasConcept C127801297 @default.
• W2000758020 hasConcept C12823836 @default.
• W2000758020 hasConcept C13373296 @default.
• W2000758020 hasConcept C137061746 @default.
• W2000758020 hasConcept C170627219 @default.
• W2000758020 hasConcept C202751555 @default.
• W2000758020 hasConcept C203014093 @default.
• W2000758020 hasConcept C207936829 @default.
• W2000758020 hasConcept C2776178377 @default.
• W2000758020 hasConcept C2778814158 @default.
• W2000758020 hasConcept C55493867 @default.
• W2000758020 hasConcept C86803240 @default.
• W2000758020 hasConcept C8891405 @default.
• W2000758020 hasConcept C95444343 @default.
• W2000758020 hasConceptScore W2000758020C119997001 @default.
• W2000758020 hasConceptScore W2000758020C127801297 @default.
• W2000758020 hasConceptScore W2000758020C12823836 @default.
• W2000758020 hasConceptScore W2000758020C13373296 @default.
• W2000758020 hasConceptScore W2000758020C137061746 @default.
• W2000758020 hasConceptScore W2000758020C170627219 @default.
• W2000758020 hasConceptScore W2000758020C202751555 @default.
• W2000758020 hasConceptScore W2000758020C203014093 @default.
• W2000758020 hasConceptScore W2000758020C207936829 @default.
• W2000758020 hasConceptScore W2000758020C2776178377 @default.
• W2000758020 hasConceptScore W2000758020C2778814158 @default.
• W2000758020 hasConceptScore W2000758020C55493867 @default.
• W2000758020 hasConceptScore W2000758020C86803240 @default.
• W2000758020 hasConceptScore W2000758020C8891405 @default.
• W2000758020 hasConceptScore W2000758020C95444343 @default.
• W2000758020 hasIssue "2" @default.
• W2000758020 hasLocation W20007580201 @default.
• W2000758020 hasLocation W20007580202 @default.
• W2000758020 hasLocation W20007580203 @default.

• next