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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000760184> ?p ?o ?g. }

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• W2000760184 abstract "Asian men were genotyped for alleles of aldehyde dehydrogenase (ALDH2) and tested on two separate occasions following oral administration of placebo and 0.75 ml/kg alcohol. Sixty minutes after beverage ingestion, event-related potentials were elicited using an auditory oddball paradigm. Repeated measures ANOVA revealed that alcohol produced significant increases in P300 latency and significant decreases in P300 amplitude compared with placebo. Subjects with ALDH2*1/2*2 genotype (n= 14) demonstrated some significantly greater P300 effects after alcohol than subjects with ALDH2*1/2*1 genotype (n= 15), despite equivalent blood alcohol concentrations. These data suggest that neurocognitive functioning may be more impaired following alcohol in subjects with an ALDH2*2 allele. These findings further suggest that a genetically controlled factor (deficiency in ALDH enzyme activity) might contribute to a decreased likelihood of alcohol intake and protection from alcoholism, because of an enhanced sensitivity to alcohol." @default.
• W2000760184 created "2016-06-24" @default.
• W2000760184 creator A5033673764 @default.
• W2000760184 creator A5043089914 @default.
• W2000760184 date "1995-06-01" @default.
• W2000760184 modified "2023-09-26" @default.
• W2000760184 title "Acute Effects of Alcohol on P300 in Asians with Different ALDH2 Genotypes" @default.
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• W2000760184 doi "https://doi.org/10.1111/j.1530-0277.1995.tb01557.x" @default.
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