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- W2000760451 abstract "The clearance from blood circulation of fluorinated liposomes made with perfluoroalkylated phosphatidylcholines was investigated in mice using liposome‐entrapped 5(6)‐carboxyfluorescein. The presence of a fluorinated core inside the membrane strongly retards their blood clearance. The fluorinated vesicles showed circulation half‐lives of up to 8.6 h, which are 6–13 and 3–6 times larger than those of similarly sized conventional distearoylphosphatidylcholine and distearoylphosphatidylcholine/cholesterol liposomes, respectively. Their blood clearance was similar to that of some polyethylene glycol (PEG)‐labelled ‘stealth’ liposomes and was dose‐independent in a 3.3–330 body weight dose range." @default.
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- W2000760451 date "1993-12-28" @default.
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- W2000760451 title "Extended in vivo blood circulation time of fluorinated liposomes" @default.
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- W2000760451 doi "https://doi.org/10.1016/0014-5793(93)80860-w" @default.
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