Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000763979> ?p ?o ?g. }
- W2000763979 endingPage "337" @default.
- W2000763979 startingPage "325" @default.
- W2000763979 abstract "The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel density. The production of pro-angiogenic molecules is increased and the production of angiogenic inhibitors is suppressed, leading to an angiogenic switch. Here we present an overview of the role of angiogenesis in multiple myeloma, the pro-angiogenic factors produced by myeloma cells and the microenvironment, and the mechanisms involved in the myeloma-induced angiogenic switch. Current data suggest that the increased bone marrow angiogenesis in multiple myeloma is due to the aberrant expression of angiogenic factors by myeloma cells, the subsequent increase in pro-angiogenic activity of normal plasma cells as a result of myeloma cell angiogenic activity, and the increased number of plasma cells overall. Hypoxia also contributes to the angiogenic properties of the myeloma marrow microenvironment. The transcription factor hypoxia-inducible factor-1α is overexpressed by myeloma cells and affects their transcriptional and angiogenic profiles. In addition, potential roles of the tumor suppressor gene inhibitor of growth family member 4 and homeobox B7 have also been recently highlighted as repressors of angiogenesis and pro-angiogenic related genes, respectively. This complex pathogenetic model of myeloma-induced angiogenesis suggests that several pro-angiogenic molecules and related genes in myeloma cells and the microenvironment are potential therapeutic targets." @default.
- W2000763979 created "2016-06-24" @default.
- W2000763979 creator A5037948411 @default.
- W2000763979 creator A5043503519 @default.
- W2000763979 creator A5065396878 @default.
- W2000763979 creator A5083314734 @default.
- W2000763979 creator A5083766802 @default.
- W2000763979 date "2011-07-07" @default.
- W2000763979 modified "2023-10-18" @default.
- W2000763979 title "Angiogenesis and Multiple Myeloma" @default.
- W2000763979 cites W1539780911 @default.
- W2000763979 cites W1550989298 @default.
- W2000763979 cites W1552949608 @default.
- W2000763979 cites W1555001167 @default.
- W2000763979 cites W1573363574 @default.
- W2000763979 cites W1580184585 @default.
- W2000763979 cites W1597321356 @default.
- W2000763979 cites W18131798 @default.
- W2000763979 cites W1896782101 @default.
- W2000763979 cites W1964370179 @default.
- W2000763979 cites W1964522660 @default.
- W2000763979 cites W1964920982 @default.
- W2000763979 cites W1965116261 @default.
- W2000763979 cites W1970614272 @default.
- W2000763979 cites W1974776888 @default.
- W2000763979 cites W1975311615 @default.
- W2000763979 cites W1977877980 @default.
- W2000763979 cites W1978506033 @default.
- W2000763979 cites W1981218425 @default.
- W2000763979 cites W1982034975 @default.
- W2000763979 cites W1984920521 @default.
- W2000763979 cites W1985147506 @default.
- W2000763979 cites W1985605024 @default.
- W2000763979 cites W1988423530 @default.
- W2000763979 cites W1989049899 @default.
- W2000763979 cites W1995827857 @default.
- W2000763979 cites W1996577023 @default.
- W2000763979 cites W1996796696 @default.
- W2000763979 cites W1999670368 @default.
- W2000763979 cites W2000292756 @default.
- W2000763979 cites W2003626058 @default.
- W2000763979 cites W2004810624 @default.
- W2000763979 cites W2005334224 @default.
- W2000763979 cites W2005833204 @default.
- W2000763979 cites W2007129479 @default.
- W2000763979 cites W2009169267 @default.
- W2000763979 cites W2010012376 @default.
- W2000763979 cites W2014245338 @default.
- W2000763979 cites W2015719404 @default.
- W2000763979 cites W2021746076 @default.
- W2000763979 cites W2022861980 @default.
- W2000763979 cites W2023147749 @default.
- W2000763979 cites W2027103801 @default.
- W2000763979 cites W2027305567 @default.
- W2000763979 cites W2033277518 @default.
- W2000763979 cites W2034378488 @default.
- W2000763979 cites W2038566520 @default.
- W2000763979 cites W2039853752 @default.
- W2000763979 cites W2041419803 @default.
- W2000763979 cites W2042831722 @default.
- W2000763979 cites W2047059447 @default.
- W2000763979 cites W2048273482 @default.
- W2000763979 cites W2048306047 @default.
- W2000763979 cites W2049991901 @default.
- W2000763979 cites W2050225501 @default.
- W2000763979 cites W2050499474 @default.
- W2000763979 cites W2053610685 @default.
- W2000763979 cites W2053966701 @default.
- W2000763979 cites W2054638358 @default.
- W2000763979 cites W2055437192 @default.
- W2000763979 cites W2056449496 @default.
- W2000763979 cites W2056776227 @default.
- W2000763979 cites W2058115529 @default.
- W2000763979 cites W2059873406 @default.
- W2000763979 cites W2060525515 @default.
- W2000763979 cites W2066402214 @default.
- W2000763979 cites W2066936999 @default.
- W2000763979 cites W2067545073 @default.
- W2000763979 cites W2068353461 @default.
- W2000763979 cites W2068831893 @default.
- W2000763979 cites W2070704155 @default.
- W2000763979 cites W2073363483 @default.
- W2000763979 cites W2074887253 @default.
- W2000763979 cites W2075422129 @default.
- W2000763979 cites W2075860887 @default.
- W2000763979 cites W2076011415 @default.
- W2000763979 cites W2079067557 @default.
- W2000763979 cites W2079068906 @default.
- W2000763979 cites W2079555075 @default.
- W2000763979 cites W2081245927 @default.
- W2000763979 cites W2082572336 @default.
- W2000763979 cites W2085027690 @default.
- W2000763979 cites W2085716871 @default.
- W2000763979 cites W2087160976 @default.
- W2000763979 cites W2087476945 @default.
- W2000763979 cites W2089222579 @default.
- W2000763979 cites W2089420293 @default.
- W2000763979 cites W2091076857 @default.