Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000764315> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2000764315 endingPage "582" @default.
- W2000764315 startingPage "573" @default.
- W2000764315 abstract "Background/Aims: Recent studies have shown that angiotensin II (Ang II) type 1 receptor blockers (ARB) may provide renal protection independent of their blood pressure-lowering effect. However, evidence for this comes from indirect methods, such as genetic or protein expression studies. In this study, we hypothesized that telmisartan, a specific ARB, applied to Ang II-stimulated mesangial cell (MC) would exert a renoprotective effect via modulation of MCs’ mechanical properties. Methods: We investigated the effect of telmisartan on Ang II-induced changes in MCs utilizing real-time atomic force microscopy (AFM) imaging and force-distance curve measurements. Results: Real-time AFM images of live MCs demonstrated that cells contracted towards the center after Ang II exposure, and telmisartan treatment abolished this change. Cellular spring constants showed that telmisartan prevented Ang II-induced MC stiffening (Ang II: 0.109 ± 0.019 N/m, Ang II + telmisartan: 0.051 ± 0.016 N/m, p < 0.005). Telmisartan-treated MCs had a significantly lower adhesion force than those of the control group (control: 0.49 ± 0.22 nN, telmisartan: 0.22 ± 0.06 nN, Ang II: 0.40 ± 0.25nN, Ang II + telmisartan: 0.27 ± 0.14 nN, p < 0.005). These results demonstrate that the dynamic contraction and mechanical properties of Ang II-stimulated MCs are restored by telmisartan. Conclusions: We report for the first time the use of AFM force-distance curves on live MCs to directly monitor changes in surface adhesion and stiffness of cells after treatment with telmisartan in real time." @default.
- W2000764315 created "2016-06-24" @default.
- W2000764315 creator A5003957784 @default.
- W2000764315 creator A5008666758 @default.
- W2000764315 creator A5012175176 @default.
- W2000764315 creator A5038869527 @default.
- W2000764315 creator A5043968841 @default.
- W2000764315 creator A5043998456 @default.
- W2000764315 creator A5072478725 @default.
- W2000764315 date "2012-01-01" @default.
- W2000764315 modified "2023-09-27" @default.
- W2000764315 title "Real-Time Monitoring of the Effects of Telmisartan on Angiotensin II-Induced Mechanical Changes in Live Mesangial Cells Using Atomic Force Microscopy" @default.
- W2000764315 cites W1963915666 @default.
- W2000764315 cites W2008779572 @default.
- W2000764315 cites W2011963991 @default.
- W2000764315 cites W2019750339 @default.
- W2000764315 cites W2041934697 @default.
- W2000764315 cites W2059728691 @default.
- W2000764315 cites W2073236176 @default.
- W2000764315 cites W2075648762 @default.
- W2000764315 cites W2081842109 @default.
- W2000764315 cites W2083600501 @default.
- W2000764315 cites W2088890344 @default.
- W2000764315 cites W2094754850 @default.
- W2000764315 cites W2098684572 @default.
- W2000764315 cites W2135369903 @default.
- W2000764315 cites W2164337499 @default.
- W2000764315 cites W2167956058 @default.
- W2000764315 cites W2170753465 @default.
- W2000764315 cites W2303555161 @default.
- W2000764315 cites W3021250193 @default.
- W2000764315 cites W3150248096 @default.
- W2000764315 doi "https://doi.org/10.1159/000339175" @default.
- W2000764315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22890312" @default.
- W2000764315 hasPublicationYear "2012" @default.
- W2000764315 type Work @default.
- W2000764315 sameAs 2000764315 @default.
- W2000764315 citedByCount "7" @default.
- W2000764315 countsByYear W20007643152012 @default.
- W2000764315 countsByYear W20007643152013 @default.
- W2000764315 countsByYear W20007643152014 @default.
- W2000764315 countsByYear W20007643152016 @default.
- W2000764315 countsByYear W20007643152018 @default.
- W2000764315 crossrefType "journal-article" @default.
- W2000764315 hasAuthorship W2000764315A5003957784 @default.
- W2000764315 hasAuthorship W2000764315A5008666758 @default.
- W2000764315 hasAuthorship W2000764315A5012175176 @default.
- W2000764315 hasAuthorship W2000764315A5038869527 @default.
- W2000764315 hasAuthorship W2000764315A5043968841 @default.
- W2000764315 hasAuthorship W2000764315A5043998456 @default.
- W2000764315 hasAuthorship W2000764315A5072478725 @default.
- W2000764315 hasBestOaLocation W20007643151 @default.
- W2000764315 hasConcept C102951782 @default.
- W2000764315 hasConcept C126322002 @default.
- W2000764315 hasConcept C134018914 @default.
- W2000764315 hasConcept C170493617 @default.
- W2000764315 hasConcept C171250308 @default.
- W2000764315 hasConcept C185592680 @default.
- W2000764315 hasConcept C192562407 @default.
- W2000764315 hasConcept C2779716603 @default.
- W2000764315 hasConcept C2908929049 @default.
- W2000764315 hasConcept C55493867 @default.
- W2000764315 hasConcept C71924100 @default.
- W2000764315 hasConcept C84393581 @default.
- W2000764315 hasConceptScore W2000764315C102951782 @default.
- W2000764315 hasConceptScore W2000764315C126322002 @default.
- W2000764315 hasConceptScore W2000764315C134018914 @default.
- W2000764315 hasConceptScore W2000764315C170493617 @default.
- W2000764315 hasConceptScore W2000764315C171250308 @default.
- W2000764315 hasConceptScore W2000764315C185592680 @default.
- W2000764315 hasConceptScore W2000764315C192562407 @default.
- W2000764315 hasConceptScore W2000764315C2779716603 @default.
- W2000764315 hasConceptScore W2000764315C2908929049 @default.
- W2000764315 hasConceptScore W2000764315C55493867 @default.
- W2000764315 hasConceptScore W2000764315C71924100 @default.
- W2000764315 hasConceptScore W2000764315C84393581 @default.
- W2000764315 hasIssue "6" @default.
- W2000764315 hasLocation W20007643151 @default.
- W2000764315 hasLocation W20007643152 @default.
- W2000764315 hasOpenAccess W2000764315 @default.
- W2000764315 hasPrimaryLocation W20007643151 @default.
- W2000764315 hasRelatedWork W1992220075 @default.
- W2000764315 hasRelatedWork W2020571025 @default.
- W2000764315 hasRelatedWork W2024736606 @default.
- W2000764315 hasRelatedWork W2033472167 @default.
- W2000764315 hasRelatedWork W2034583712 @default.
- W2000764315 hasRelatedWork W2063619316 @default.
- W2000764315 hasRelatedWork W2091193686 @default.
- W2000764315 hasRelatedWork W2151139437 @default.
- W2000764315 hasRelatedWork W2169225653 @default.
- W2000764315 hasRelatedWork W2414846389 @default.
- W2000764315 hasVolume "35" @default.
- W2000764315 isParatext "false" @default.
- W2000764315 isRetracted "false" @default.
- W2000764315 magId "2000764315" @default.
- W2000764315 workType "article" @default.