FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000764611> ?p ?o ?g. }

• W2000764611 endingPage "44" @default.
• W2000764611 startingPage "35" @default.
• W2000764611 abstract "All-<i>trans</i>-retinoic acid is a potent developmental toxicant in all species examined. The teratogenic risk of topical all-<i> trans</i>-retinoic acid is reviewed. Experimental studies are limited because of the high maternal toxicity, including skin irritation, with doses below those resulting in significant teratogenic response with other application routes, such as oral application. The maximal systemic availability reported for transdermal exposure of all-<i> trans</i>-retinoic acid was 5-6% in the rat, 9.6% in the monkey (48% with dermatitic skin) and 5-7% in the human. Oral administration of threshold teratogenic doses of all-<i> trans</i>-retinoic acid (6 mg/kg/day) to Wistar rats and Swiss hare rabbits resulted in embryonic area under the concentration time curve levels (approximately 1,000 ng&#183;h/g) which were 2- to 4-fold higher than the endogenous all-<i> trans</i>-retinoic acid levels; corresponding maternal plasma area under the concentration time curve values were 98 and 321 ng&#183;h/ml in rat and rabbit, respectively. The 4-oxo-metab-olite was also found in maternal plasma and embryo. Large, controlled studies on the possible developmental toxicity of topical all-<i> trans</i> -retinoic acid in the human are not available. Isolated case reports appeared in the literature claiming teratogenic outcome resembling effects after oral iso-tretinoin use or those observed in experimental studies with oral or paren-teral all-<i> trans</i>-retinoic acid administration. The dose absorbed from daily cosmetic or therapeutic application of all-<i> trans</i> -retinoic acid is expected to be below 0.015 mg/kg, which is at least 30-fold lower than the lowest teratogenic dose of isotretinoin in the human. Topical all-<i> trans</i> -retinoic acid application did not appreciably alter endogenous plasma retinoid levels. The influence of nutrition, diurnal variation and in particular oral vitamin A supplements are more important determinants of plasma retinoic acid compounds than topical all-<i> trans</i> -retinoic acid. These results imply a low risk of therapeutic or cosmetic application of topical all-<i>trans</i>-retinoic acid. However, the highly specific spatial and temporal distribution of binding proteins and nuclear receptors in the embryo suggests that even small alterations in endogenous levels of all-<i> trans</i> -retinoic acid in the embryo may alter crucial developmental processes such as morphogenes; this aspect should be further investigated." @default.
• W2000764611 created "2016-06-24" @default.
• W2000764611 creator A5026995646 @default.
• W2000764611 date "1993-01-01" @default.
• W2000764611 modified "2023-10-01" @default.
• W2000764611 title "Embryotoxicity and Teratogenicity of Topical Retinoic Acid" @default.
• W2000764611 doi "https://doi.org/10.1159/000211162" @default.
• W2000764611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8142110" @default.
• W2000764611 hasPublicationYear "1993" @default.
• W2000764611 type Work @default.
• W2000764611 sameAs 2000764611 @default.
• W2000764611 citedByCount "71" @default.
• W2000764611 countsByYear W20007646112013 @default.
• W2000764611 countsByYear W20007646112014 @default.
• W2000764611 countsByYear W20007646112015 @default.
• W2000764611 countsByYear W20007646112016 @default.
• W2000764611 countsByYear W20007646112017 @default.
• W2000764611 countsByYear W20007646112018 @default.
• W2000764611 countsByYear W20007646112019 @default.
• W2000764611 countsByYear W20007646112020 @default.
• W2000764611 countsByYear W20007646112021 @default.
• W2000764611 countsByYear W20007646112023 @default.
• W2000764611 crossrefType "journal-article" @default.
• W2000764611 hasAuthorship W2000764611A5026995646 @default.
• W2000764611 hasConcept C104317684 @default.
• W2000764611 hasConcept C126322002 @default.
• W2000764611 hasConcept C134018914 @default.
• W2000764611 hasConcept C172680121 @default.
• W2000764611 hasConcept C179335377 @default.
• W2000764611 hasConcept C185592680 @default.
• W2000764611 hasConcept C2775954498 @default.
• W2000764611 hasConcept C2777056448 @default.
• W2000764611 hasConcept C2779234561 @default.
• W2000764611 hasConcept C2779963572 @default.
• W2000764611 hasConcept C2780473477 @default.
• W2000764611 hasConcept C2781121885 @default.
• W2000764611 hasConcept C29730261 @default.
• W2000764611 hasConcept C54355233 @default.
• W2000764611 hasConcept C55493867 @default.
• W2000764611 hasConcept C65290608 @default.
• W2000764611 hasConcept C71924100 @default.
• W2000764611 hasConcept C79410662 @default.
• W2000764611 hasConcept C86803240 @default.
• W2000764611 hasConcept C98274493 @default.
• W2000764611 hasConceptScore W2000764611C104317684 @default.
• W2000764611 hasConceptScore W2000764611C126322002 @default.
• W2000764611 hasConceptScore W2000764611C134018914 @default.
• W2000764611 hasConceptScore W2000764611C172680121 @default.
• W2000764611 hasConceptScore W2000764611C179335377 @default.
• W2000764611 hasConceptScore W2000764611C185592680 @default.
• W2000764611 hasConceptScore W2000764611C2775954498 @default.
• W2000764611 hasConceptScore W2000764611C2777056448 @default.
• W2000764611 hasConceptScore W2000764611C2779234561 @default.
• W2000764611 hasConceptScore W2000764611C2779963572 @default.
• W2000764611 hasConceptScore W2000764611C2780473477 @default.
• W2000764611 hasConceptScore W2000764611C2781121885 @default.
• W2000764611 hasConceptScore W2000764611C29730261 @default.
• W2000764611 hasConceptScore W2000764611C54355233 @default.
• W2000764611 hasConceptScore W2000764611C55493867 @default.
• W2000764611 hasConceptScore W2000764611C65290608 @default.
• W2000764611 hasConceptScore W2000764611C71924100 @default.
• W2000764611 hasConceptScore W2000764611C79410662 @default.
• W2000764611 hasConceptScore W2000764611C86803240 @default.
• W2000764611 hasConceptScore W2000764611C98274493 @default.
• W2000764611 hasIssue "Suppl. 1" @default.
• W2000764611 hasLocation W20007646111 @default.
• W2000764611 hasLocation W20007646112 @default.
• W2000764611 hasOpenAccess W2000764611 @default.
• W2000764611 hasPrimaryLocation W20007646111 @default.
• W2000764611 hasRelatedWork W1989246541 @default.
• W2000764611 hasRelatedWork W1990273725 @default.
• W2000764611 hasRelatedWork W2000764611 @default.
• W2000764611 hasRelatedWork W2017899161 @default.
• W2000764611 hasRelatedWork W2037681128 @default.
• W2000764611 hasRelatedWork W2076671646 @default.
• W2000764611 hasRelatedWork W2093859333 @default.
• W2000764611 hasRelatedWork W2344485696 @default.
• W2000764611 hasRelatedWork W2346017608 @default.
• W2000764611 hasRelatedWork W2470196498 @default.
• W2000764611 hasVolume "6" @default.
• W2000764611 isParatext "false" @default.
• W2000764611 isRetracted "false" @default.
• W2000764611 magId "2000764611" @default.
• W2000764611 workType "article" @default.