Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000764886> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2000764886 endingPage "1460" @default.
- W2000764886 startingPage "1455" @default.
- W2000764886 abstract "Peroxynitrite anions may play a role in normothermic renal ischemia and reperfusion. The purpose of this study was to determine if endogenous peroxynitrite anion is involved in renal preservation injury.Experiments were conducted in isolated canine renal tubules and in a canine autotransplant model of hypothermic preservation injury.Isolated renal tubules demonstrated progressive loss of membrane transport function after reperfusion with increasing cold storage times in UW solution as assessed by tetraethylammonium cation transport (TEA). This transport defect was not altered by reperfusion in the presence of WW85, a peroxynitrite decomposition catalyst. Likewise, tubule LDH release was not altered by WW85. Renal tubules did not demonstrate any evidence of peroxynitrite formation after cold storage (0-120 h) or after subsequent reperfusion in vitro as measured by nitrotyrosine adduct formation. Addition of exogenous peroxynitrite (1 mM) directly to freshly isolated renal tubules produced strong nitrotyrosine signals but failed to alter membrane function (TEA uptake). Conversely, SIN-1, a peroxynitrite generator molecule, failed to produce a nitrotyrosine signal in extracted renal tubule proteins but significantly impaired transport function. Finally, function of cold stored canine autografts was not affected by the scavenging of peroxynitrite anions (WW85) before kidney harvest and immediately at reperfusion. Tissue biopsies from cold stored kidney autografts also failed to show evidence of peroxynitrite synthesis either after cold storage (72 h) or after kidney transplantation (60 min reperfusion).This study concludes that peroxynitrite anions are not formed and are not involved in renal preservation injury." @default.
- W2000764886 created "2016-06-24" @default.
- W2000764886 creator A5030427766 @default.
- W2000764886 creator A5058049602 @default.
- W2000764886 creator A5058050294 @default.
- W2000764886 creator A5068245717 @default.
- W2000764886 creator A5069388250 @default.
- W2000764886 creator A5083369269 @default.
- W2000764886 date "2005-11-27" @default.
- W2000764886 modified "2023-10-06" @default.
- W2000764886 title "Role of Peroxynitrite Anion in Renal Hypothermic Preservation Injury" @default.
- W2000764886 cites W1530421518 @default.
- W2000764886 cites W1923609106 @default.
- W2000764886 cites W1964267038 @default.
- W2000764886 cites W1987741979 @default.
- W2000764886 cites W2007983312 @default.
- W2000764886 cites W2011233979 @default.
- W2000764886 cites W2011307569 @default.
- W2000764886 cites W2014325326 @default.
- W2000764886 cites W2021727050 @default.
- W2000764886 cites W2038297924 @default.
- W2000764886 cites W2038654549 @default.
- W2000764886 cites W2062483277 @default.
- W2000764886 cites W2064347448 @default.
- W2000764886 cites W2064517350 @default.
- W2000764886 cites W2068565569 @default.
- W2000764886 cites W2069728361 @default.
- W2000764886 cites W2110565948 @default.
- W2000764886 cites W2118458451 @default.
- W2000764886 cites W2127525287 @default.
- W2000764886 cites W2127526059 @default.
- W2000764886 cites W2149346633 @default.
- W2000764886 cites W2150202468 @default.
- W2000764886 doi "https://doi.org/10.1097/01.tp.0000181099.20099.d1" @default.
- W2000764886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16340791" @default.
- W2000764886 hasPublicationYear "2005" @default.
- W2000764886 type Work @default.
- W2000764886 sameAs 2000764886 @default.
- W2000764886 citedByCount "8" @default.
- W2000764886 countsByYear W20007648862016 @default.
- W2000764886 crossrefType "journal-article" @default.
- W2000764886 hasAuthorship W2000764886A5030427766 @default.
- W2000764886 hasAuthorship W2000764886A5058049602 @default.
- W2000764886 hasAuthorship W2000764886A5058050294 @default.
- W2000764886 hasAuthorship W2000764886A5068245717 @default.
- W2000764886 hasAuthorship W2000764886A5069388250 @default.
- W2000764886 hasAuthorship W2000764886A5083369269 @default.
- W2000764886 hasConcept C126322002 @default.
- W2000764886 hasConcept C144027150 @default.
- W2000764886 hasConcept C181199279 @default.
- W2000764886 hasConcept C185592680 @default.
- W2000764886 hasConcept C2777622882 @default.
- W2000764886 hasConcept C2778784160 @default.
- W2000764886 hasConcept C2779385521 @default.
- W2000764886 hasConcept C2780091579 @default.
- W2000764886 hasConcept C2780114680 @default.
- W2000764886 hasConcept C2780795997 @default.
- W2000764886 hasConcept C2988529969 @default.
- W2000764886 hasConcept C541997718 @default.
- W2000764886 hasConcept C55493867 @default.
- W2000764886 hasConcept C71924100 @default.
- W2000764886 hasConcept C86803240 @default.
- W2000764886 hasConceptScore W2000764886C126322002 @default.
- W2000764886 hasConceptScore W2000764886C144027150 @default.
- W2000764886 hasConceptScore W2000764886C181199279 @default.
- W2000764886 hasConceptScore W2000764886C185592680 @default.
- W2000764886 hasConceptScore W2000764886C2777622882 @default.
- W2000764886 hasConceptScore W2000764886C2778784160 @default.
- W2000764886 hasConceptScore W2000764886C2779385521 @default.
- W2000764886 hasConceptScore W2000764886C2780091579 @default.
- W2000764886 hasConceptScore W2000764886C2780114680 @default.
- W2000764886 hasConceptScore W2000764886C2780795997 @default.
- W2000764886 hasConceptScore W2000764886C2988529969 @default.
- W2000764886 hasConceptScore W2000764886C541997718 @default.
- W2000764886 hasConceptScore W2000764886C55493867 @default.
- W2000764886 hasConceptScore W2000764886C71924100 @default.
- W2000764886 hasConceptScore W2000764886C86803240 @default.
- W2000764886 hasIssue "10" @default.
- W2000764886 hasLocation W20007648861 @default.
- W2000764886 hasLocation W20007648862 @default.
- W2000764886 hasOpenAccess W2000764886 @default.
- W2000764886 hasPrimaryLocation W20007648861 @default.
- W2000764886 hasRelatedWork W1974185399 @default.
- W2000764886 hasRelatedWork W2005899179 @default.
- W2000764886 hasRelatedWork W2008861924 @default.
- W2000764886 hasRelatedWork W2058137293 @default.
- W2000764886 hasRelatedWork W2060263803 @default.
- W2000764886 hasRelatedWork W2077921614 @default.
- W2000764886 hasRelatedWork W2155169902 @default.
- W2000764886 hasRelatedWork W2161946150 @default.
- W2000764886 hasRelatedWork W2993194087 @default.
- W2000764886 hasRelatedWork W397751367 @default.
- W2000764886 hasVolume "80" @default.
- W2000764886 isParatext "false" @default.
- W2000764886 isRetracted "false" @default.
- W2000764886 magId "2000764886" @default.
- W2000764886 workType "article" @default.