Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000765601> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2000765601 abstract "Migraine is a common neurological disorder with a global prevalence around 10% [1]. Several studies showed that migraine is influenced by genetic and environmental factors [2]. The female-to-male ratio of migraine prevalence is 3- to 4-fold higher among women than men[3]. The role of common variants of GABA genes in the X-chromosome in migraine susceptibility was assessed, aiming to explain the differences in disease frequency between males and females. An association study with 188 unrelated cases and 287 migraine-free controls age- and ethnic matched was performed. The case-control ratio was 1:1.5. Candidate genes were selected based on their possible role in pathophysiology of migraine.Thirty-two tagging SNPs were selected in three genes (GABRE, GABRA3 and GABRQ) and genotyping was performed by SNaPshot. Allelic, genotypic and haplotypic frequencies were compared between cases and controls and multiple testing corrections were performed. Also, gene-gene interactions were analyzed. The Results for allelic associations revealed five nominal significant associations and three trends for association. In what concerns genotypic frequencies, four noteworthy results were found in GABRE and GABRA3 genes. After multiple testing correction, two allelic associations remained significant (GABRA3 and GABRE) and one genotypic association resisted to Bonferroni correction (GABRE), all in the females group. No significant results were found in the haplotypic analyses but an additive effect was observed between two SNPs of GABRA3 and two of GABRE. These findings show, for the first time, evidence of a possible involvement of common variants in GABA receptors in migraine susceptibility and in gender-specific liability." @default.
- W2000765601 created "2016-06-24" @default.
- W2000765601 creator A5038408079 @default.
- W2000765601 creator A5039195824 @default.
- W2000765601 creator A5041806703 @default.
- W2000765601 creator A5045536338 @default.
- W2000765601 creator A5064251463 @default.
- W2000765601 creator A5082554496 @default.
- W2000765601 creator A5083909148 @default.
- W2000765601 creator A5089477553 @default.
- W2000765601 date "2013-02-01" @default.
- W2000765601 modified "2023-10-12" @default.
- W2000765601 title "Unraveling migraine susceptibility in females: the involvement of GABA genes" @default.
- W2000765601 cites W2031806681 @default.
- W2000765601 cites W2045777987 @default.
- W2000765601 doi "https://doi.org/10.1186/1129-2377-14-s1-p11" @default.
- W2000765601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3619994" @default.
- W2000765601 hasPublicationYear "2013" @default.
- W2000765601 type Work @default.
- W2000765601 sameAs 2000765601 @default.
- W2000765601 citedByCount "1" @default.
- W2000765601 countsByYear W20007656012019 @default.
- W2000765601 crossrefType "journal-article" @default.
- W2000765601 hasAuthorship W2000765601A5038408079 @default.
- W2000765601 hasAuthorship W2000765601A5039195824 @default.
- W2000765601 hasAuthorship W2000765601A5041806703 @default.
- W2000765601 hasAuthorship W2000765601A5045536338 @default.
- W2000765601 hasAuthorship W2000765601A5064251463 @default.
- W2000765601 hasAuthorship W2000765601A5082554496 @default.
- W2000765601 hasAuthorship W2000765601A5083909148 @default.
- W2000765601 hasAuthorship W2000765601A5089477553 @default.
- W2000765601 hasBestOaLocation W20007656011 @default.
- W2000765601 hasConcept C104317684 @default.
- W2000765601 hasConcept C118552586 @default.
- W2000765601 hasConcept C16568411 @default.
- W2000765601 hasConcept C169760540 @default.
- W2000765601 hasConcept C2778541695 @default.
- W2000765601 hasConcept C2779526319 @default.
- W2000765601 hasConcept C2991975920 @default.
- W2000765601 hasConcept C54355233 @default.
- W2000765601 hasConcept C60644358 @default.
- W2000765601 hasConcept C71924100 @default.
- W2000765601 hasConcept C86803240 @default.
- W2000765601 hasConceptScore W2000765601C104317684 @default.
- W2000765601 hasConceptScore W2000765601C118552586 @default.
- W2000765601 hasConceptScore W2000765601C16568411 @default.
- W2000765601 hasConceptScore W2000765601C169760540 @default.
- W2000765601 hasConceptScore W2000765601C2778541695 @default.
- W2000765601 hasConceptScore W2000765601C2779526319 @default.
- W2000765601 hasConceptScore W2000765601C2991975920 @default.
- W2000765601 hasConceptScore W2000765601C54355233 @default.
- W2000765601 hasConceptScore W2000765601C60644358 @default.
- W2000765601 hasConceptScore W2000765601C71924100 @default.
- W2000765601 hasConceptScore W2000765601C86803240 @default.
- W2000765601 hasIssue "S1" @default.
- W2000765601 hasLocation W20007656011 @default.
- W2000765601 hasLocation W20007656012 @default.
- W2000765601 hasLocation W20007656013 @default.
- W2000765601 hasOpenAccess W2000765601 @default.
- W2000765601 hasPrimaryLocation W20007656011 @default.
- W2000765601 hasRelatedWork W2014052946 @default.
- W2000765601 hasRelatedWork W2021870942 @default.
- W2000765601 hasRelatedWork W2045099844 @default.
- W2000765601 hasRelatedWork W2102570667 @default.
- W2000765601 hasRelatedWork W2149235621 @default.
- W2000765601 hasRelatedWork W2237085382 @default.
- W2000765601 hasRelatedWork W3164072648 @default.
- W2000765601 hasRelatedWork W4240934142 @default.
- W2000765601 hasRelatedWork W4251353665 @default.
- W2000765601 hasRelatedWork W4299301975 @default.
- W2000765601 hasVolume "14" @default.
- W2000765601 isParatext "false" @default.
- W2000765601 isRetracted "false" @default.
- W2000765601 magId "2000765601" @default.
- W2000765601 workType "article" @default.