FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000765868> ?p ?o ?g. }

• W2000765868 endingPage "100" @default.
• W2000765868 startingPage "88" @default.
• W2000765868 abstract "l-nucleoside analogues are now largely used as antiviral drugs for the treatment of viral infections like HBV, HCV and HIV. However, in order to be fully active, they need to be phosphorylated by cellular or viral kinases. Human 3-phosphogycerate kinase (hPGK) was shown to catalyze the last step of activation of l-enantiomers and thus constitutes an attractive target for theoretical predictions of its phosphorylation efficiency. Molecular dynamics simulations were carried out with four different nucleotides (d-/l-ADP and d-/l-CDP) in complex with hPGK and 1,3-bisphospho-d-glycerate (bPG). The binding affinities of CDPs (both enantiomers) for hPGK were found very weak while d- and l-ADP were better substrates. Interestingly, the binding affinity of the bPG substrate was found to be lower in presence of d-ADP than l-ADP which indicates a potential antagonistic effect on one substrate to the other. A detailed analysis of the simulations unravels important dynamic conditions for efficient phosphorylation. Indeed, as previously described for the natural substrate, the hinge bending motion of the domains upon substrates binding should be more correlated and directional. Interestingly, the unforeseen finding was the larger dynamics freedoms observed for the substrates that was favored by the protein atoms flexibility around the nucleobase binding site." @default.
• W2000765868 created "2016-06-24" @default.
• W2000765868 creator A5029378838 @default.
• W2000765868 creator A5043151942 @default.
• W2000765868 creator A5048595334 @default.
• W2000765868 creator A5056997764 @default.
• W2000765868 creator A5077105275 @default.
• W2000765868 creator A5082526237 @default.
• W2000765868 date "2011-07-01" @default.
• W2000765868 modified "2023-09-25" @default.
• W2000765868 title "Ligand chirality effects on the dynamics of human 3-phosphoglycerate kinase: Comparison between d- and l-nucleotides" @default.
• W2000765868 cites W1522634924 @default.
• W2000765868 cites W1967701811 @default.
• W2000765868 cites W1970871948 @default.
• W2000765868 cites W1976499671 @default.
• W2000765868 cites W1977206788 @default.
• W2000765868 cites W1982357973 @default.
• W2000765868 cites W1982492006 @default.
• W2000765868 cites W1987212163 @default.
• W2000765868 cites W1991092929 @default.
• W2000765868 cites W1991794210 @default.
• W2000765868 cites W2002511030 @default.
• W2000765868 cites W2017196167 @default.
• W2000765868 cites W2017342479 @default.
• W2000765868 cites W2026196547 @default.
• W2000765868 cites W2029043718 @default.
• W2000765868 cites W2030866185 @default.
• W2000765868 cites W2044772240 @default.
• W2000765868 cites W2045276000 @default.
• W2000765868 cites W2050659161 @default.
• W2000765868 cites W2050747066 @default.
• W2000765868 cites W2063089010 @default.
• W2000765868 cites W2066849290 @default.
• W2000765868 cites W2095145098 @default.
• W2000765868 cites W2098295536 @default.
• W2000765868 cites W2109790715 @default.
• W2000765868 cites W2121397622 @default.
• W2000765868 cites W2131375911 @default.
• W2000765868 cites W2150462928 @default.
• W2000765868 cites W2150981663 @default.
• W2000765868 cites W2156397518 @default.
• W2000765868 cites W2162166182 @default.
• W2000765868 cites W2404439418 @default.
• W2000765868 doi "https://doi.org/10.1016/j.abb.2011.04.014" @default.
• W2000765868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21549683" @default.
• W2000765868 hasPublicationYear "2011" @default.
• W2000765868 type Work @default.
• W2000765868 sameAs 2000765868 @default.
• W2000765868 citedByCount "2" @default.
• W2000765868 countsByYear W20007658682015 @default.
• W2000765868 countsByYear W20007658682018 @default.
• W2000765868 crossrefType "journal-article" @default.
• W2000765868 hasAuthorship W2000765868A5029378838 @default.
• W2000765868 hasAuthorship W2000765868A5043151942 @default.
• W2000765868 hasAuthorship W2000765868A5048595334 @default.
• W2000765868 hasAuthorship W2000765868A5056997764 @default.
• W2000765868 hasAuthorship W2000765868A5077105275 @default.
• W2000765868 hasAuthorship W2000765868A5082526237 @default.
• W2000765868 hasConcept C104317684 @default.
• W2000765868 hasConcept C107824862 @default.
• W2000765868 hasConcept C11960822 @default.
• W2000765868 hasConcept C121332964 @default.
• W2000765868 hasConcept C124668440 @default.
• W2000765868 hasConcept C12554922 @default.
• W2000765868 hasConcept C147597530 @default.
• W2000765868 hasConcept C184235292 @default.
• W2000765868 hasConcept C185592680 @default.
• W2000765868 hasConcept C18903297 @default.
• W2000765868 hasConcept C20621625 @default.
• W2000765868 hasConcept C2776543447 @default.
• W2000765868 hasConcept C2777289219 @default.
• W2000765868 hasConcept C2778564446 @default.
• W2000765868 hasConcept C2780283098 @default.
• W2000765868 hasConcept C512185932 @default.
• W2000765868 hasConcept C55493867 @default.
• W2000765868 hasConcept C59593255 @default.
• W2000765868 hasConcept C62520636 @default.
• W2000765868 hasConcept C71240020 @default.
• W2000765868 hasConcept C7602139 @default.
• W2000765868 hasConcept C86803240 @default.
• W2000765868 hasConceptScore W2000765868C104317684 @default.
• W2000765868 hasConceptScore W2000765868C107824862 @default.
• W2000765868 hasConceptScore W2000765868C11960822 @default.
• W2000765868 hasConceptScore W2000765868C121332964 @default.
• W2000765868 hasConceptScore W2000765868C124668440 @default.
• W2000765868 hasConceptScore W2000765868C12554922 @default.
• W2000765868 hasConceptScore W2000765868C147597530 @default.
• W2000765868 hasConceptScore W2000765868C184235292 @default.
• W2000765868 hasConceptScore W2000765868C185592680 @default.
• W2000765868 hasConceptScore W2000765868C18903297 @default.
• W2000765868 hasConceptScore W2000765868C20621625 @default.
• W2000765868 hasConceptScore W2000765868C2776543447 @default.
• W2000765868 hasConceptScore W2000765868C2777289219 @default.
• W2000765868 hasConceptScore W2000765868C2778564446 @default.
• W2000765868 hasConceptScore W2000765868C2780283098 @default.
• W2000765868 hasConceptScore W2000765868C512185932 @default.
• W2000765868 hasConceptScore W2000765868C55493867 @default.
• W2000765868 hasConceptScore W2000765868C59593255 @default.

• next