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• W2000767002 abstract "Purpose.: To characterize the age dependence of shape, refractive power, and refractive index of isolated lenses from nonhuman primates. Methods.: Measurements were performed on ex vivo lenses from cynomolgus monkeys (cyno: n = 120; age, 2.7–14.3 years), rhesus monkeys (n = 61; age, 0.7–13.3 years), and hamadryas baboons (baboon: n = 16; age, 1.7–27.3 years). Lens thickness, diameter, and surface curvatures were measured with an optical comparator. Lens refractive power was measured with a custom optical system based on the Scheiner principle. The refractive contributions of the gradient, the surfaces, and the equivalent refractive index were calculated with optical ray-tracing software. The age dependence of the optical and biometric parameters was assessed. Results.: Over the measured age range isolated lens thickness decreased (baboon: −0.04, cyno: −0.05, and rhesus: −0.06 mm/y) and equatorial diameter increased (logarithmically for the baboon and rhesus, and linearly for cyno: 0.07 mm/y). The isolated lens surfaces flattened and the corresponding refractive power from the surfaces decreased with age (−0.33, −0.48, and −0.68 D/y). The isolated lens equivalent refractive index decreased (only significant for the baboon, −0.001 D/y), and as a result the total isolated lens refractive power decreased with age (baboon: −1.26, cyno: −0.97, and rhesus: −1.76 D/y). Conclusions.: The age-dependent trends in the optical and biometric properties, growth, and aging, of nonhuman primate lenses are similar to those of the pre-presbyopic human lens. As the lens ages, the decrease in refractive contributions from the gradient refractive index causes a rapid age-dependent decrease in maximally accommodated lens refractive power." @default.
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• W2000767002 date "2010-04-01" @default.
• W2000767002 modified "2023-09-26" @default.
• W2000767002 title "Refractive Power and Biometric Properties of the Nonhuman Primate Isolated Crystalline Lens" @default.
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• W2000767002 doi "https://doi.org/10.1167/iovs.09-3905" @default.
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