FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000768369> ?p ?o ?g. }

• W2000768369 endingPage "472" @default.
• W2000768369 startingPage "470" @default.
• W2000768369 abstract "Purines and pyrimidines, either as nucleobases or as polymeric nucleic acids, are not deemed to be essential because de novo synthetic pathways are present for synthesis of these molecules. However, a growing body of evidence suggests that nucleic acids and/or the corresponding purine and pyrimidine bases are conditionally required for normal responses of specific organs or systems of the body. The conditions that expose this heretofore recognized requirement for dietary nucleotides are those under which there is rapid cell replication. Endogenous purines and pyrimidines are synthesized de novo from amino acids and other molecules. Purines are synthesized from glycine, glutamine, asparate, and CO2 formate, while pyrimidines are synthesized from asparate or glutamine, NH3, and C02. Both bases are ribosylated to form nucleosides; these compounds are phosphorylated via PRPP to form nucleotides. These nucleotides can be converted to dior triphosphates, or degraded to nucleosides intracellularly. After removal of the ribose (or deoxyribose) moiety, the pyrimidine nucleobase uracil or cytosine, or the purine nucleobase hypoxanthine, can be further catabolized. Alternately, these bases can be salvaged via use of the substrate PRPP to form the 5 monophosphate by the phosphoribosyltranferases in the cell.’ Previous studies on the fate of dietary purines and pyrimidines suggested limited oral bioavailability compared with a similar parenteral dose.’ The gut has limited adenine synthetic capacity, and dietary purines are largely extracted at the level of the gut. More recent studies suggest a more profound influence of dietary nucleotides on the organism as a whole. LopezNavarro et al.3 demonstrated that rodents fed a nucleotidefree diet showed a significant early decrease in hepatic levels of purine and pyrimidine nucleotides, while a group supplemented with dietary purine and pyrimidine nucleotides demonstrated no such change. This biochemical perturbation was associated with a profound and persistent decrease in hepatic RNA content in rats on the nucleotide-free diet. In contrast, rats supplemented with dietary nucleotides maintained normal hepatic RNA content. The influence of exogenous nucleotides or hepatic RNA levels is greater for the pyrimidine nucleotides. Lopez-Navarro documented that hepatic pyrimidine nucleotide levels are much more vulnerable to dietary restriction. Supplementation of the diet failed to return hepatic pyrimidine nucleotide levels totally to normal, although this may have been due to an inadequate provision of the oral dose of pyrimidine nucleotides. Further confirmation of the critical role of dietary pyrimidine nucleotides was reflected in the recent study of hepatic RNA labeling of hens and mice fed C-labeled algae. Dietary pyrimidines were documented to be significantly incorporated into hepatic nucleotide pools, while virtually no dietary purine nucleosides were used for hepatic nucleic acid synthesis.5 Moreover, dietary uracil, but not cytosine, significantly contributed to hepatic nucleoside synthesis. These authors concluded that pyrimidines, as either the base uracil or as nucleosides, were conditionally essential nutrients. The nutrition experiments described above imply that these profound changes in hepatic RNA content and nucleotide pools will result in suboptimal responses in nucleotide-deprived hosts. The experimental models that document the consequences of these diet-induced hepatic nucleotide levels test three host responses: hepatic regeneration following resection or injury; gut maturation and response to injury; and hostspecific and nonspecific immune responses. Following 70% hepatic resection, a parenteral nutrition regimen containing 10% of amino acid nitrogen as nucleotides and nucleosides significantly enhanced hepatic regeneration.6 Hepatic injury following galactosamine administration was reduced by parenteral provision of a nucleotide/nucleoside mixture.’ These findings suggest that the supply of ribosomal RNA that controls the proliferative response to hepatic resection or chemical injury may be affected by the availability of dietary nucleotides. Moreover, it appears to be the dietary pyrimidine nucleotides or nucleobases that are critical, since the hepatic levels of these substrates correlate best with diet-induced changes in hepatic RNA content. Another rapidly proliferating cell pool of the body appears to be vulnerable to restriction of dietary nucleotides. The content of the small intestinal RNA was significantly reduced in animals deprived of dietary nucleotides or nucleobases.’ This was true in the presence and in the absence of protein in the diet. Furthermore, presence of nucleotides in the diet appeared" @default.
• W2000768369 created "2016-06-24" @default.
• W2000768369 creator A5027596271 @default.
• W2000768369 creator A5039325266 @default.
• W2000768369 date "1997-05-01" @default.
• W2000768369 modified "2023-09-26" @default.
• W2000768369 title "Dietary nucleotides: A conditional requirement" @default.
• W2000768369 cites W1530346045 @default.
• W2000768369 cites W1766625674 @default.
• W2000768369 cites W1805963454 @default.
• W2000768369 cites W2003567705 @default.
• W2000768369 cites W2006472704 @default.
• W2000768369 cites W2012158337 @default.
• W2000768369 cites W2058578773 @default.
• W2000768369 cites W2069492594 @default.
• W2000768369 cites W2076981287 @default.
• W2000768369 cites W2089849882 @default.
• W2000768369 cites W2090161937 @default.
• W2000768369 cites W2091949015 @default.
• W2000768369 cites W2094143382 @default.
• W2000768369 cites W2094854491 @default.
• W2000768369 cites W4239225716 @default.
• W2000768369 cites W81641852 @default.
• W2000768369 doi "https://doi.org/10.1016/s0899-9007(97)00103-2" @default.
• W2000768369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9225342" @default.
• W2000768369 hasPublicationYear "1997" @default.
• W2000768369 type Work @default.
• W2000768369 sameAs 2000768369 @default.
• W2000768369 citedByCount "47" @default.
• W2000768369 countsByYear W20007683692012 @default.
• W2000768369 countsByYear W20007683692013 @default.
• W2000768369 countsByYear W20007683692015 @default.
• W2000768369 countsByYear W20007683692016 @default.
• W2000768369 countsByYear W20007683692017 @default.
• W2000768369 countsByYear W20007683692018 @default.
• W2000768369 countsByYear W20007683692019 @default.
• W2000768369 countsByYear W20007683692020 @default.
• W2000768369 countsByYear W20007683692021 @default.
• W2000768369 countsByYear W20007683692022 @default.
• W2000768369 crossrefType "journal-article" @default.
• W2000768369 hasAuthorship W2000768369A5027596271 @default.
• W2000768369 hasAuthorship W2000768369A5039325266 @default.
• W2000768369 hasConcept C104317684 @default.
• W2000768369 hasConcept C512185932 @default.
• W2000768369 hasConcept C55493867 @default.
• W2000768369 hasConcept C86803240 @default.
• W2000768369 hasConceptScore W2000768369C104317684 @default.
• W2000768369 hasConceptScore W2000768369C512185932 @default.
• W2000768369 hasConceptScore W2000768369C55493867 @default.
• W2000768369 hasConceptScore W2000768369C86803240 @default.
• W2000768369 hasIssue "5" @default.
• W2000768369 hasLocation W20007683691 @default.
• W2000768369 hasLocation W20007683692 @default.
• W2000768369 hasOpenAccess W2000768369 @default.
• W2000768369 hasPrimaryLocation W20007683691 @default.
• W2000768369 hasRelatedWork W1592060630 @default.
• W2000768369 hasRelatedWork W1970112624 @default.
• W2000768369 hasRelatedWork W2075541528 @default.
• W2000768369 hasRelatedWork W2092808452 @default.
• W2000768369 hasRelatedWork W2335033221 @default.
• W2000768369 hasRelatedWork W2415449752 @default.
• W2000768369 hasRelatedWork W2422532047 @default.
• W2000768369 hasRelatedWork W2423544833 @default.
• W2000768369 hasRelatedWork W3022338549 @default.
• W2000768369 hasRelatedWork W4379233589 @default.
• W2000768369 hasVolume "13" @default.
• W2000768369 isParatext "false" @default.
• W2000768369 isRetracted "false" @default.
• W2000768369 magId "2000768369" @default.
• W2000768369 workType "article" @default.