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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000769711> ?p ?o ?g. }

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• W2000769711 abstract "We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein." @default.
• W2000769711 created "2016-06-24" @default.
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• W2000769711 date "2007-02-12" @default.
• W2000769711 modified "2023-10-03" @default.
• W2000769711 title "GRIM-19 associates with the serine protease HtrA2 for promoting cell death" @default.
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• W2000769711 doi "https://doi.org/10.1038/sj.onc.1210287" @default.
• W2000769711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17297443" @default.
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