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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000771161> ?p ?o ?g. }

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• W2000771161 abstract "Indirubin derivatives were identified as potent FLT3 tyrosine kinase inhibitors with anti-proliferative activity at acute myeloid leukemic cell lines, RS4;11 and MV4;11 which express FLT3-WT and FLT3-ITD mutation, respectively. Among several 5 and 5′-substituted indirubin derivatives, 5-fluoro analog, 13 exhibited potent inhibitory activity at FLT3 (IC50 = 15 nM) with more than 100-fold selectivity versus 6 other kinases and potent anti-proliferative effect for MV4;11 cells (IC50 = 72 nM) with 30-fold selectivity versus RS4;11 cells. Cell cycle analysis indicated that compound 13 induced cell cycle arrest at G0/G1 phase in MV4;11 cells." @default.
• W2000771161 created "2016-06-24" @default.
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• W2000771161 date "2010-03-01" @default.
• W2000771161 modified "2023-10-01" @default.
• W2000771161 title "Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells" @default.
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• W2000771161 doi "https://doi.org/10.1016/j.bmcl.2010.01.039" @default.
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