FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000773294> ?p ?o ?g. }

• W2000773294 endingPage "656" @default.
• W2000773294 startingPage "648" @default.
• W2000773294 abstract "Increased O-linked attachment of β-N-acetylglucosamine (O-GlcNAc) to proteins has been implicated in the adverse effects of diabetes on the heart, although this has typically been based on models of severe hyperglycemia. Diabetes has also been associated with dysregulation of autophagy, a critical cell survival process; however, little is known regarding autophagy in the diabetic heart or whether this is influenced by O-GlcNAcylation or hemodynamic stress.Young male rats were assigned to control (12% kcal fat/19% protein/69% carbohydrate), high fat diet (60/19/21%) and type 2 diabetic (high fat diet+low dose streptozotocin) groups for 8 weeks, followed by sham or pressure overload surgeries; animals were sacrificed 8 weeks after surgery.A modest increase in arterial pressure resulted in no significant effects on cardiac function in control or high fat groups, while diabetic hearts exhibited contractile dysfunction and increased apoptosis and scar formation. Immunoprecipitation studies revealed, for the first time, that Beclin-1, which plays a critical early role in autophagy, and the anti-apoptotic Bcl-2, are targets for O-GlcNAcylation. Interestingly, we also found that cardiomyocytes isolated from type 2 diabetic db/db mice exhibited a blunted autophagic response and this was at least partially reversed by inhibiting glucose entry into the hexosamine biosynthesis pathway, which regulates O-GlcNAc synthesis. We also found that acutely augmenting O-GlcNAc levels in non-diabetic cardiomyocytes mimicked the effects of diabetes by blunting autophagic signaling.These data suggest that O-GlcNAc-mediated inhibition of autophagy may contribute to the abnormal response of diabetic hearts to hemodynamic stress." @default.
• W2000773294 created "2016-06-24" @default.
• W2000773294 creator A5015447173 @default.
• W2000773294 creator A5016096111 @default.
• W2000773294 creator A5031015047 @default.
• W2000773294 creator A5053149684 @default.
• W2000773294 date "2013-03-01" @default.
• W2000773294 modified "2023-09-25" @default.
• W2000773294 title "Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart" @default.
• W2000773294 cites W1970228194 @default.
• W2000773294 cites W1970834072 @default.
• W2000773294 cites W1972336737 @default.
• W2000773294 cites W1973472942 @default.
• W2000773294 cites W1976761774 @default.
• W2000773294 cites W1994239968 @default.
• W2000773294 cites W1994411647 @default.
• W2000773294 cites W1998787508 @default.
• W2000773294 cites W2013684433 @default.
• W2000773294 cites W2014943313 @default.
• W2000773294 cites W2018559323 @default.
• W2000773294 cites W2022575054 @default.
• W2000773294 cites W2028228064 @default.
• W2000773294 cites W2034132952 @default.
• W2000773294 cites W2048371464 @default.
• W2000773294 cites W2057713336 @default.
• W2000773294 cites W2062383366 @default.
• W2000773294 cites W2068153705 @default.
• W2000773294 cites W2075358633 @default.
• W2000773294 cites W2077731318 @default.
• W2000773294 cites W2081098379 @default.
• W2000773294 cites W2089342328 @default.
• W2000773294 cites W2096317893 @default.
• W2000773294 cites W2101519888 @default.
• W2000773294 cites W2107746022 @default.
• W2000773294 cites W2120647467 @default.
• W2000773294 cites W2135574023 @default.
• W2000773294 cites W2140069893 @default.
• W2000773294 cites W2145461802 @default.
• W2000773294 cites W2152205887 @default.
• W2000773294 cites W2158841256 @default.
• W2000773294 cites W2163105403 @default.
• W2000773294 cites W2165075711 @default.
• W2000773294 cites W2462266144 @default.
• W2000773294 doi "https://doi.org/10.1016/j.lfs.2012.06.011" @default.
• W2000773294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3477499" @default.
• W2000773294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728715" @default.
• W2000773294 hasPublicationYear "2013" @default.
• W2000773294 type Work @default.
• W2000773294 sameAs 2000773294 @default.
• W2000773294 citedByCount "88" @default.
• W2000773294 countsByYear W20007732942012 @default.
• W2000773294 countsByYear W20007732942013 @default.
• W2000773294 countsByYear W20007732942014 @default.
• W2000773294 countsByYear W20007732942015 @default.
• W2000773294 countsByYear W20007732942016 @default.
• W2000773294 countsByYear W20007732942017 @default.
• W2000773294 countsByYear W20007732942018 @default.
• W2000773294 countsByYear W20007732942019 @default.
• W2000773294 countsByYear W20007732942020 @default.
• W2000773294 countsByYear W20007732942021 @default.
• W2000773294 countsByYear W20007732942022 @default.
• W2000773294 countsByYear W20007732942023 @default.
• W2000773294 crossrefType "journal-article" @default.
• W2000773294 hasAuthorship W2000773294A5015447173 @default.
• W2000773294 hasAuthorship W2000773294A5016096111 @default.
• W2000773294 hasAuthorship W2000773294A5031015047 @default.
• W2000773294 hasAuthorship W2000773294A5053149684 @default.
• W2000773294 hasBestOaLocation W20007732942 @default.
• W2000773294 hasConcept C111566952 @default.
• W2000773294 hasConcept C126322002 @default.
• W2000773294 hasConcept C134018914 @default.
• W2000773294 hasConcept C178853913 @default.
• W2000773294 hasConcept C185592680 @default.
• W2000773294 hasConcept C190283241 @default.
• W2000773294 hasConcept C203522944 @default.
• W2000773294 hasConcept C2776553924 @default.
• W2000773294 hasConcept C2777180221 @default.
• W2000773294 hasConcept C2778198053 @default.
• W2000773294 hasConcept C2778271984 @default.
• W2000773294 hasConcept C2778797674 @default.
• W2000773294 hasConcept C2779280383 @default.
• W2000773294 hasConcept C3018791406 @default.
• W2000773294 hasConcept C55493867 @default.
• W2000773294 hasConcept C555293320 @default.
• W2000773294 hasConcept C71924100 @default.
• W2000773294 hasConcept C86803240 @default.
• W2000773294 hasConceptScore W2000773294C111566952 @default.
• W2000773294 hasConceptScore W2000773294C126322002 @default.
• W2000773294 hasConceptScore W2000773294C134018914 @default.
• W2000773294 hasConceptScore W2000773294C178853913 @default.
• W2000773294 hasConceptScore W2000773294C185592680 @default.
• W2000773294 hasConceptScore W2000773294C190283241 @default.
• W2000773294 hasConceptScore W2000773294C203522944 @default.
• W2000773294 hasConceptScore W2000773294C2776553924 @default.
• W2000773294 hasConceptScore W2000773294C2777180221 @default.
• W2000773294 hasConceptScore W2000773294C2778198053 @default.
• W2000773294 hasConceptScore W2000773294C2778271984 @default.
• W2000773294 hasConceptScore W2000773294C2778797674 @default.

• next